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Titolo:
Benzotriazonine as a new core structure for the design of CCK-receptor antagonists
Autore:
Escherich, A; Escrieut, C; Fourmy, D; Moroder, L;
Indirizzi:
Max Planck Inst Biochem, D-82152 Martinsried, Germany Max Planck Inst Biochem Martinsried Germany D-82152 Martinsried, Germany CHU Rangueil, INSERM U151, F-31054 Toulouse, France CHU Rangueil Toulouse France F-31054 SERM U151, F-31054 Toulouse, France
Titolo Testata:
JOURNAL OF PEPTIDE SCIENCE
fascicolo: 3, volume: 5, anno: 1999,
pagine: 155 - 158
SICI:
1075-2617(199903)5:3<155:BAANCS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ; DERIVATIVES; 2,3,4,5,6,7-HEXAHYDRO-1H-1,4,7-BENZOTRIAZONINE; POTENT;
Keywords:
benzotriazonine; peptide hormone; CCK; gastrin; CCK-receptor antagonists;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Moroder, L Max Planck Inst Biochem, Klopferspitz 18A, D-82152 Martinsried,Germany Max Planck Inst Biochem Klopferspitz 18A Martinsried Germany D-82152
Citazione:
A. Escherich et al., "Benzotriazonine as a new core structure for the design of CCK-receptor antagonists", J PEPT SCI, 5(3), 1999, pp. 155-158

Abstract

The search for heterocyclic scaffolds for the design of non-peptidic and highly selective agonists or antagonists of peptide hormone receptors led to4-N-benzyl-2,3,4,5,6,7-hexahydro-1H-1,4,7-benzotriazonin-2,6-dione with a 9-membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK-A receptor with a 54-fold selectivity over the CCK-B/gastrin receptor. Copyright (C) 1999 European PeptideSociety and John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:06:04