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Titolo:
Increased fecal bile acid excretion and changes in the circulating bile acid pool are involved in the hypocholesterolemic and gallstone preventive actions of psyllium in hamsters
Autore:
Trautwein, EA; Kunath-Rau, A; Erbersdobler, HF;
Indirizzi:
Univ Kiel, Inst Nutr & Food sci, D-24105 Kiel, Germany Univ Kiel Kiel Germany D-24105 st Nutr & Food sci, D-24105 Kiel, Germany
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 4, volume: 129, anno: 1999,
pagine: 896 - 902
SICI:
0022-3166(199904)129:4<896:IFBAEA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL-LOWERING ACTION; LDL-CHOLESTEROL; DIETARY PSYLLIUM; PLASMA LDL; GUINEA-PIG; RATS; CHOLESTYRAMINE; 7-ALPHA-HYDROXYLASE; METABOLISM; MECHANISMS;
Keywords:
psyllium; cholestyramine; cholesterol-lowering; bile acids; hamsters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Trautwein, EA Novarhs Nutr Res Unit, Maastricht, Netherlands Novarhs Nutr Res Unit Maastricht Netherlands Netherlands
Citazione:
E.A. Trautwein et al., "Increased fecal bile acid excretion and changes in the circulating bile acid pool are involved in the hypocholesterolemic and gallstone preventive actions of psyllium in hamsters", J NUTR, 129(4), 1999, pp. 896-902

Abstract

The lipid-lowering effect of psyllium (PSY) is well established. Enhanced fecal bile acid excretion and a stimulation of hepatic bile acid synthesis are discussed as primary mechanisms of this action. To further examine the effect of bile acid excretion and specifically of compositional alterationsin the bile acid pool on the cholesterol-lowering and gallstone-preventingaction of PSY, male golden Syrian hamsters were fed lithogenic diets containing 5 g/100 g fat, 0.4 g/100 g cholesterol and 0 (control), 4 or 6% PSY or 1% cholestyramine (CHY). PSY significantly lowered plasma total cholesterol and triacylglycerol at a magnitude comparable to that induced by CHY, Although hepatic cholesteryl eater accumulation was completely inhibited by CHY, PSY did not prevent the hepatic storage of esterified cholesterol, PSY and CHY caused distinct alterations in the bile acid profile. PSY caused a selective reduction of taurine-conjugated bile acids, especially of taurochenodeoxycholate. As a result, the glycine:taurine conjugation and the cholate:chenodeoxycholate ratios were significantly higher in PSY-fed hamsters. PSY and CHY normalized the lithogenic index and prevented cholesterol gallstone formation compared with controls. Daily fecal bile acid excretion was similar to 400% greater in hamsters fed 6% PSY, whereas CHY caused an 11-fold increase. Daily neutral sterol excretion did not differ in PSY-fed hamsters but was >100% greater in those fed CHY than in controls. These data emphasize the potent lipid-lowering effect of PSY, Increased fecal bile acid excretion and alterations of the circulating bile acid pool by removal of dihydroxy bile acids (e.g,, taurochenodeoxycholate) appear to be main modulators of the hypocholesterolemic action of PSY by leading to an up-regulationof hepatic bile acid synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:55:25