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Titolo:
De novo development of a cavernous malformation of the spinal cord following spinal axis radiation - Case report
Autore:
Maraire, JN; Abdulrauf, SI; Berger, S; Knisely, J; Awad, IA;
Indirizzi:
Yale6520v, Sch Med, Neurovasc Surg Program, Dept Neurosurg, New Haven, CT 0 Yale Univ New Haven CT USA 06520 Program, Dept Neurosurg, New Haven, CT 0 Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 Diagnost Radiol, New Haven, CT 06510 USA Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA Yale Univ New Haven CT USA 06510 herapeut Radiol, New Haven, CT 06510 USA
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 4, volume: 90, anno: 1999, supplemento:, S
pagine: 234 - 238
SICI:
0022-3085(199904)90:4<234:DNDOAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICAL PRESENTATION; SURGICAL-MANAGEMENT; ANGIOMAS; APPEARANCE;
Keywords:
cavernous malformation; radiation therapy; spinal cord; vascular malformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Awad, IA Yale5,niv, Sch Med, Neurovasc Surg Program, Dept Neurosurg, CedarSt,TMP 40 Yale Univ Cedar St,TMP 405 New Haven CT USA 06520 Cedar St,TMP 40
Citazione:
J.N. Maraire et al., "De novo development of a cavernous malformation of the spinal cord following spinal axis radiation - Case report", J NEUROSURG, 90(4), 1999, pp. 234-238

Abstract

Analysis of recent reports has suggested that cavernous malformations (CMs) of the brain may have an acquired pathogenesis and a dynamic pathophysiological composition, with documented appearance of new lesions in familial cases and following radiotherapy. The authors report the first case of demonstrated de novo formation of an intramedullary CM following spinal radiation therapy. A 17 year-old boy presented with diabetes insipidus and delayed puberty. Evaluation of endocrine levels revealed hypopituitarism, and magnetic resonance (MR) imaging demonstrated an infundibular mass. The patient underwent apterional craniotomy and removal of an infundibular germinoma. The MR image of the spine demonstrated normal results. The patient received craniospinal radiation therapy and did well. He presented 5 years later with acute onset of back pain, lower-extremity weakness and numbness, and difficulty with urination. An MR image obtained of the spine revealed an intramedullary T-7 lesion; its signal characteristics were consistent with a CM. The patient was initially managed conservatively but developed progressivemyelopathy and partial Brown-Sequard syndrome. Although he received high-dose steroids and bed rest, his symptoms worsened. He underwent a costotransversectomy and excision of a hemorrhagic vascular lesion via an anterolateral myelotomy. Pathological examination confirmed features of a CM. The patient has done well and was walking without assistance within 4 weeks of surgery. De novo genesis of CMs may be associated with prior radiation therapy to the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:19:28