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Titolo:
Phosphorylation of CREB in axon-induced Schwann cell proliferation
Autore:
Lee, MM; Badache, A; DeVries, GH;
Indirizzi:
Edward Hines Vet Adm Hosp, Hines, IL 60141 USA Edward Hines Vet Adm Hosp Hines IL USA 60141 dm Hosp, Hines, IL 60141 USA Univs,alif Los Angeles, Mental Retardat Res Ctr, Dept Neurobiol, Los Angele Univ Calif Los Angeles Los Angeles CA USA 90024 ept Neurobiol, Los Angele Univ,Calif Los Angeles, Mental Retardat Res Ctr, Dept Psychiat, Los Angeles Univ Calif Los Angeles Los Angeles CA USA 90024 ept Psychiat, Los Angeles Freidrich Miescher Inst, Basel, Switzerland Freidrich Miescher Inst Basel Switzerland cher Inst, Basel, Switzerland LoyolaAUniv, Med Ctr, Dept Anat Cell Biol & Neurobiol, Chicago, IL 60611 US Loyola Univ Chicago IL USA 60611 l Biol & Neurobiol, Chicago, IL 60611 US
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 6, volume: 55, anno: 1999,
pagine: 702 - 712
SICI:
0360-4012(19990315)55:6<702:POCIAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING-PROTEIN; AXOLEMMA-ENRICHED FRACTIONS; NUCLEAR FACTOR CREB; CYCLIC-AMP; KINASE-C; GENE-EXPRESSION; IN-VITRO; GROWTH; CAMP; NEUREGULIN;
Keywords:
Schwann cell; axolemma; CREB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: DeVries, GH Edward Hines Vet Adm Hosp, Res 151, Hines, IL 60141 USA EdwardHines Vet Adm Hosp Res 151 Hines IL USA 60141 60141 USA
Citazione:
M.M. Lee et al., "Phosphorylation of CREB in axon-induced Schwann cell proliferation", J NEUROSC R, 55(6), 1999, pp. 702-712

Abstract

Axonal contact regulates Schwann cell (SC) proliferation during development. However, the intracellular signal transduction pathways involved in the axon-induced proliferation of SC have not been described, We have previously shown that SC proliferation induced by axolemma-enriched fractions (AEF) is accompanied by increased expression of cyclic AMP-responsive element binding protein, CREB. We now report the AEF and dorsal root ganglion neuritic-induced signal transduction pathway(s) which regulate the phosphorylation of CREB that correlate with the SC proliferative response, The phosphorylated form of CREB was significantly increased after 16 hr of axonal stimulation, continued to increase for 48 hr, and subsequently decreased as monitored by immunocytochemistry and Western blot analysis. treatment with protein kinase A (PKA) inhibitor, H89, completely abolished both the CREB activation and SC proliferation. In contrast, treatment with protein kinase C (PKC) inhibitor (bisindolylmaleimide) inhibited AEF-induced SC proliferation, butdid not immediately affect CREB phosphorylation, These data are consistentwith the view that PKA and PKC pathways are essential for AEF-induced SC proliferation. Since PKC can influence SC proliferation without initially affecting CREB phosphorylation, PKC may regulate SC proliferation at pathwaysdistal to the immediate CREB activation. (C) 1999 Wileg-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:33:55