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Titolo:
Utility of a tripolar stimulating electrode for eliciting dopamine releasein the rat striatum
Autore:
Bergstrom, BP; Garris, PA;
Indirizzi:
Illinoisl,tate Univ, Cellular & Integrat Physiol Sect, Dept Biol Sci, Norma Illinois State Univ Normal IL USA 61790 hysiol Sect, Dept Biol Sci, Norma
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 2, volume: 87, anno: 1999,
pagine: 201 - 208
SICI:
0165-0270(19990301)87:2<201:UOATSE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED EXTRACELLULAR DOPAMINE; CYCLIC VOLTAMMETRY; IN-VIVO; OVERFLOW; HETEROGENEITY; INNERVATION; INHIBITION; FOREBRAIN; SYSTEMS; EFFLUX;
Keywords:
dopamine; tripolar stimulating electrode; voltammetry; medial forebrain bundle; ventral mesencephalon; caudate putamen; nucleus accumbens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Garris, PA Illinoisl,tate Univ, Cellular & Integrat Physiol Sect, Dept Biol Sci, Norma Illinois State Univ Normal IL USA 61790 , Dept Biol Sci, Norma
Citazione:
B.P. Bergstrom e P.A. Garris, "Utility of a tripolar stimulating electrode for eliciting dopamine releasein the rat striatum", J NEUROSC M, 87(2), 1999, pp. 201-208

Abstract

The present study evaluated tripolar stimulating electrodes for eliciting dopamine release in the rat brain in vivo. Stimulating electrodes were placed either in the medial forebrain bundle or in the ventral mcsencephalon associated with the ventral tegmental area and substantia nigra. The concentration of extracellular dopamine was monitored in dopamine terminal fields at 100-ms intervals using fast-scan cyclic voltammetry at carbon-fiber microelectrodes. To characterize the stimulated area, recordings were collected in several striatal regions including the caudate putamen and the core and shell of the nucleus accumbens. The tripolar electrode was equally effective in stimulating dopamine release in medial and lateral regions of the striatum. In contrast, responses evoked by a bipolar electrode were typically greater in one mediolateral edge versus the other. The added size of the tripolar electrode did not appear to cause complications as signals were stable over the course of the experiment (3 h). Subsets of mesostriatal dopamineneurons could also be selectively activated using the tripolar electrode in excellent agreement with previously described topography. Taken together,these results suggested that the tripolar stimulating electrode is well suited for studying the regulation of midbrain dopamine neurons in vivo. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 03/06/20 alle ore 00:08:12