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Titolo:
Hypothalamic involvement in the regulation of maternal behaviour in the rat: Inhibitory roles for the ventromedial hypothalamus and the dorsal/anterior hypothalamic areas
Autore:
Bridges, RS; Mann, PE; Coppeta, JS;
Indirizzi:
Tufts Univ, Sch Vet Med, Dept Biomed Sci, N Grafton, MA 01536 USA Tufts Univ N Grafton MA USA 01536 ept Biomed Sci, N Grafton, MA 01536 USA
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 4, volume: 11, anno: 1999,
pagine: 259 - 266
SICI:
0953-8194(199904)11:4<259:HIITRO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREOPTIC AREA; FEMALE RATS; MESSENGER-RNA; EFFERENT CONNECTIONS; NULLIPAROUS RATS; BRAIN-REGIONS; VIRGIN RATS; ESTRADIOL; NUCLEUS; ONSET;
Keywords:
oestradiol; NMA; neurotoxic lesions; parental care;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bridges, RS Tufts536iv, Sch Vet Med, Dept Biomed Sci, 200 Westboro Rd, N Grafton, MA 01 Tufts Univ 200 Westboro Rd N Grafton MA USA 01536 afton, MA 01
Citazione:
R.S. Bridges et al., "Hypothalamic involvement in the regulation of maternal behaviour in the rat: Inhibitory roles for the ventromedial hypothalamus and the dorsal/anterior hypothalamic areas", J NEUROENDO, 11(4), 1999, pp. 259-266

Abstract

The present report examines the possible involvement of the ventromedial hypothalamus (VMH), the dorsal hypothalamus (DH), and the anterior hypothalamic area (AHA) in the regulation of maternal behaviour in the female rat. In a series of experiments it was found that either infusions of saline or lowering cannulas into the VMH stimulated a rapid onset of maternal behaviour in progesterone plus oestrogen-primed, nulliparous rats, The stimulatory effect of cannula lowering into the VMH on maternal behaviour was shown to be steroid-dependent. Next, the involvement of cell bodies located in the DH/AHA in maternal behaviour was examined after bilateral lesions of these regions with the neurotoxin, N-methyl-D-aspartic acid (NMA). NMA lesions of the DH/AHA stimulated a rapid onset of maternal behaviour in oestrogen-treated, nulliparous rats, while NMA lesions in non-steroid-treated animals or vehicle infusions in steroid or non-steroid-treated rats failed to induce arapid onset of behaviour. In a final study the effects of NMA lesions of the VMH were evaluated, As in AHA lesioned rats, NMA lesions of the VMH stimulated a fast onset of maternal behaviour in steroid-primed females. These findings indicate that the VMH as well as the DH/AHA exert chronic steroid-dependent inhibitory influences on the induction of maternal behaviour.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:04:39