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Titolo:
HGF/SF in mammary epithelial growth and morphogenesis: In vitro and in vivo models
Autore:
Kamalati, T; Niranjan, B; Yant, J; Buluwela, L;
Indirizzi:
Inst Child Hlth, Div Canc Biol, London WC1 1EH, England Inst Child Hlth London England WC1 1EH anc Biol, London WC1 1EH, England UnivdLondon Imperial Coll Sci Technol & Med, Div Med, London W6 8RF, Englan Univ London Imperial Coll Sci Technol & Med London England W6 8RF Englan
Titolo Testata:
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
fascicolo: 1, volume: 4, anno: 1999,
pagine: 69 - 77
SICI:
1083-3021(199901)4:1<69:HIMEGA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR SCATTER FACTOR; RECEPTOR TYROSINE KINASE; C-MET RECEPTOR; DUCTAL MORPHOGENESIS; CELL MOTILITY; FACTOR/SCATTER FACTOR; GLAND DEVELOPMENT; GENE-EXPRESSION; HEPATOCYTE; FAMILY;
Keywords:
HGF/SF; c-MET; mammary morphogenesis; mammary development; primary mammary cells; transduced mammary glands;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Kamalati, T Inst Child Hlth, Div Canc Biol, 30 Guilford St, London WC1 1EH, England Inst Child Hlth 30 Guilford St London England WC1 1EH England
Citazione:
T. Kamalati et al., "HGF/SF in mammary epithelial growth and morphogenesis: In vitro and in vivo models", J MAMMARY G, 4(1), 1999, pp. 69-77

Abstract

HGF/SF is a multifunctional cytokine which through binding to its cellularreceptor, c-MET, can elicit mitogenic, morphogenic acid motogenic responses in target cells. Expression of HGF/SF and c-MET has been shown to be: critical in early embryogenesis affecting development of many organs and tissues. The effects of HGF/SF4 on established human and mouse mammary cell lines have previously been reported. This review describes the source and targets for HGF/ SF in both human and mouse mammary tissue and discusses the effects of HGF/SF on primary mouse and human mammary epithelial cells in vitro, detailing the individual response of the two epithelial sub-population ofcells which comprise this organ. Additionally, the effects of HGF/SF overexpression on mouse mammary gland development in vivo, are summarized.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:59:55