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Titolo:
MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie
Autore:
Adjou, KT; Demaimay, R; Deslys, JP; Lasmezas, CI; Beringue, V; Demart, S; Lamoury, F; Seman, M; Dormont, D;
Indirizzi:
CEA, Serv Neurovirol, DSV,DRM, CRSSA, F-92265 Fontenay Aux Roses, France CEA Fontenay Aux Roses France F-92265 F-92265 Fontenay Aux Roses, France Univ,Paris 07, Inst Jacques Monod, Lab Immunodifferenciat, F-75251 Paris 05 Univ Paris 07 Paris France 05 , Lab Immunodifferenciat, F-75251 Paris 05
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 80, anno: 1999,
parte:, 4
pagine: 1079 - 1085
SICI:
0022-1317(199904)80:<1079:MAWABD>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CREUTZFELDT-JAKOB-DISEASE; INCUBATION PERIOD; SPONGIFORM ENCEPHALOPATHIES; POLYENE ANTIBIOTICS; INFECTED HAMSTERS; PRION DISEASES; MOUSE SCRAPIE; BSE; PROTEIN; DELAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Adjou, KT CEA,ontenayeurovirol, DSV,DRM, CRSSA, BP 6,60-68 Ave Gen Leclerc, F-92265 F CEA BP 6,60-68 Ave Gen Leclerc Fontenay Aux Roses France F-92265
Citazione:
K.T. Adjou et al., "MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie", J GEN VIROL, 80, 1999, pp. 1079-1085

Abstract

Amphotericin B (AmB) has been shown to delay hamster scrapie, Infectivity studies have been performed previously using AmB in order to understand therelationship between the accumulation of an abnormal isoform (PrPres) of the prion protein and 263K scrapie agent replication in the brain. The firststudy reported that AmB had no effect upon agent replication, although it delayed the development of both clinical signs and PrPres accumulation. However, subsequent experiments using the same model showed a significant effect both on agent replication and PrPres accumulation early in infection. This fundamental discrepancy was assumed to be linked to differences in experimental protocols. In order to unravel the issue, a new experiment has beenperformed encompassing different protocols and using an AmB derivative, MS-8209, that can be used at higher doses because of its lower toxicity. The findings of this study exclude the suspected differences in the protocols as the reason for previous conflicting results, and suggest strongly that these discrepancies were due to a low dose of AmB causing a 'threshold effect'. Overall, this study indicates that, in this model, PrPres cannot be dissociated from infectivity by polyene antibiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:12:08