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Titolo:
Low grade supratentorial astrocytomas in adults: Management, immunohistochemical analysis and long-term follow-up
Autore:
Malham, G; Moonesinghe, S; Synek, B; Anderson, N; Bok, A;
Indirizzi:
Auckland Hosp, Dept Neurosurg, Auckland, New Zealand Auckland Hosp Auckland New Zealand ept Neurosurg, Auckland, New Zealand Auckland Hosp, Dept Neurol, Auckland, New Zealand Auckland Hosp AucklandNew Zealand , Dept Neurol, Auckland, New Zealand Univ Auckland, Sch Med, Dept Pathol, Auckland, New Zealand Univ Auckland Auckland New Zealand , Dept Pathol, Auckland, New Zealand
Titolo Testata:
JOURNAL OF CLINICAL NEUROSCIENCE
fascicolo: 3, volume: 5, anno: 1998,
pagine: 304 - 309
SICI:
0967-5868(199807)5:3<304:LGSAIA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY KI-67; ABERRANT P53 EXPRESSION; CEREBRAL HEMISPHERES; RADIATION-THERAPY; HUMAN GLIOMAS; PROLIFERATING CELLS; GENETIC ALTERATIONS; PROGNOSTIC FACTORS; LABELING INDEX; BRAIN-TUMORS;
Keywords:
adult; astrocytoma; Ki-67; low-grade; p53; radiotherapy surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Malham, G Auckland Hosp, Dept Neurosurg, Private Bag 92024, Auckland, New Zealand Auckland Hosp Private Bag 92024 Auckland New Zealand w Zealand
Citazione:
G. Malham et al., "Low grade supratentorial astrocytomas in adults: Management, immunohistochemical analysis and long-term follow-up", J CL NEUROS, 5(3), 1998, pp. 304-309

Abstract

A retrospective review of supratentorial, low-grade astrocytomas in adultsover a 10-year period (1983-1993) was performed. All 62 patients bad computed tomography and surgery with histological and immunohistochemical analysis of the tumour, Radiotherapy was administered to all patients, regardlessof the extent of surgical resection, Multivariate analysis showed that ageof the patient at the time of surgery (P = 0.008) and female sex (P = 0.031) were the most important indicators of improved survival, No significant survival advantage was found with any particular symptom or symptom duration, Neither presence of a tumour cyst nor site of the tumour affected survival, Histological grading (St Anne-Mayo system) found 61 grade II astrocytomas (98%) and one grade I tumour. Six tumours (10%) were protoplasmic astrocytomas and 56 cases (90%) were diffuse fibrillary astrocytomas. Proliferation index derived from Ki-67 antibody staining and the presence of p53 protein expression were not significantly correlated with survival. Most patients underwent biopsy (79%) with 8% undergoing subtotal and 13% total resection. Increased extent of surgical removal showed a trend towards an improved survival (P = 0.05). No survival advantage was found with increasing radiotherapy dose. Median survival in the study population was 5.1 years, with survival rates of 70% at 2 years and 53% at 5 years. The follow-up period ranged from 1 to 10.5 years, Younger age, female sex and the extent of surgical resection are important prognostic factors in the management of low-gradeastrocytomas, whereas the efficacy of postoperative radiotherapy needs further evaluation, The prognostic significance of Ki-67 and p53 expression inlow-grade astrocytomas remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:15:04