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Titolo:
The effects of neonatal basal forebrain lesions on cognition: Towards understanding the developmental role of the cholinergic basal forebrain
Autore:
Berger-Sweeney, J;
Indirizzi:
Wellesley Coll, Dept Biol Sci, Wellesley, MA 02181 USA Wellesley Coll Wellesley MA USA 02181 t Biol Sci, Wellesley, MA 02181 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 7-8, volume: 16, anno: 1998,
pagine: 603 - 612
SICI:
0736-5748(199811/12)16:7-8<603:TEONBF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOWNS-SYNDROME; RAT-BRAIN; NUCLEUS BASALIS; SEX-DIFFERENCES; RECEPTOR SUBUNIT; ANIMAL-MODEL; NGF RECEPTOR; NEURONS; SYSTEM; HIPPOCAMPUS;
Keywords:
acetylcholine; cortical development; dendritic development; hippocampus; neocortex; developmental disabilities; Rett syndrome; Down syndrome; sex differences; 192 IgG saporin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Berger-Sweeney, J Wellesley Coll, Dept Biol Sci, Wellesley, MA 02181 USA Wellesley Coll Wellesley MA USA 02181 ley, MA 02181 USA
Citazione:
J. Berger-Sweeney, "The effects of neonatal basal forebrain lesions on cognition: Towards understanding the developmental role of the cholinergic basal forebrain", INT J DEV N, 16(7-8), 1998, pp. 603-612

Abstract

Abnormal development of the cholinergic basal forebrain has been implicated in numerous developmental disabilities such as Rett Syndrome and Down Syndrome. This review summarizes recent data using two rodent animal models that involve interrupting cholinergic basal forebrain projections on postnatal day 1 and postnatal day 7 when basal forebrain fibers are beginning to innervate their neocortical and hippocampal targets, respectively. In one model, electrolytic lesions in mice aimed at the basal forebrain on postnatal day 1 transiently reduce cholinergic markers in neocortex which induce permanent alterations in neocortical anatomy that correlate with impairments oncognitive tasks. Furthermore, the lesion effects are sex dependent. In another model, 192 IgG saporin lesions in rats on postnatal day 7 permanently reduce cholinergic markers in neocortex and hippocampus, and result in mildimpairments in spatial processing, acquisition and exploratory activities. These data suggest that during the first postnatal week of development thecholinergic basal forebrain system is critical For normal neocortical differentiation and? possibly synaptogenesis in neural circuits that will be important for spatial memory and acquisition of spatial data. During the second postnatal week of development, the cholinergic basal forebrain system appears to take on a role largely similar to its adult role in selective attention and processing of new information. These studies also suggest strongly that interrupting cholinergic basal forebrain innervation of neocortex and hippocampus leads to anatomical and neurochemical abnormalities that may serve as neural substrates for some of the cognitive deficits seen in disorders such as Rett Syndrome and Down Syndrome. (C) 1999 ISDN. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 25/01/20 alle ore 16:15:08