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Titolo:
Levels of transforming growth factor alpha (TGF-alpha) in human cerebrospinal fluid
Autore:
Van Setten, GB; Edstrom, L; Stibler, H; Rasmussen, S; Schultz, G;
Indirizzi:
Karolinska Inst, St Eriks Eye Clin, S-11282 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-11282 Clin, S-11282 Stockholm, Sweden Karolinska Hosp, Dept Clin Neurosci, Div Neurol, S-17176 Stockholm, SwedenKarolinska Hosp Stockholm Sweden S-17176 urol, S-17176 Stockholm, Sweden Univ Florida, Dept Obstet & Gynecol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Gynecol, Gainesville, FL 32611 USA Univ Florida, Dept Ophthalmol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 hthalmol, Gainesville, FL 32611 USA
Titolo Testata:
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
fascicolo: 2, volume: 17, anno: 1999,
pagine: 131 - 134
SICI:
0736-5748(199904)17:2<131:LOTGFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BETA; RECEPTOR; CELLS; BRAIN; MICE; RAT;
Keywords:
EGF (epidermal growth factor); TGF-alpha (transforming growth factor alpha); liquor; cerebrospinal fluid; embryology; wound healing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Van Setten, GB Karolinskadenst, St Eriks Eye Clin, Fleminggatan 22, S-11282 Stockholm, Swe Karolinska Inst Fleminggatan 22 Stockholm Sweden S-11282 e
Citazione:
G.B. Van Setten et al., "Levels of transforming growth factor alpha (TGF-alpha) in human cerebrospinal fluid", INT J DEV N, 17(2), 1999, pp. 131-134

Abstract

In this study, ate investigated cerebrospinal fluid of patients with various neurological symptoms for the presence of transforming growth factor alpha (TGF-alpha). 41 samples of cerebrospinal fluid were collected by lumbar puncture performed routinely due to the clinical suspicion of neurological disease from 22 females (age 15-80 years, median 42 years) and from 19 males (age 18-82 years, median 48 years). A highly sensitive and specific radioimmunoassay was used to determine the concentration of TGF-alpha in the samples. The detection limit of the assay was about 200 pg TGF-alpha. There was no cross-reactivity to human EGF. We showed CSF indeed does contain TGF alpha. As TGF-alpha was detected in all 41 samples investigated, this growthth factor appears to be a constant component of CSF. The mean concentration was 5.5 ng TGF-alpha (S.D. +/- 2.7 pg/ml, range 1.1 to 13.9 pg/ml). Therewas no significant correlation between TGF-alpha concentration in CSF and age (r = -0.006) and there was no significant difference between females (mean 5.8 +/- 3.10 pg/ml) and males (mean 5.2 +/- 1.96 pg/ml). No diagnosis was over represented in patients with TGF-alpha concentrations above or below 1 S. D. off the mean. However. highest concentrations of TGF-alpha. were found in the group of patients with peripheral neurological sensory disfunctions and polyneuropathy. We conclude that TGF-alpha is not only a constantcomponent of human cerebrospinal fluid in adults but could also be significantly involved in the pathophysiology of various neurological diseases. The earlier hypothesis that TGF-alpha could mainly have a role in brain development needs hence to be re-evaluated. (C) 1999 ISDN. Published by ElsevierScience Ltd. All rights reserved.

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Documento generato il 28/11/20 alle ore 21:47:27