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Titolo:
Morphological and functional changes in the colonic epithelial cells in a rabbit model of colitis
Autore:
Homaidan, FR; Zhao, LM; Palaia, T; Donovan, V; Burakoff, R;
Indirizzi:
Amer Univ Beirut, Dept Physiol, New York, NY 10022 USA Amer Univ Beirut New York NY USA 10022 pt Physiol, New York, NY 10022 USA Winthrop Univ Hosp, Div Gastroenterol, Mineola, NY 11501 USA Winthrop UnivHosp Mineola NY USA 11501 troenterol, Mineola, NY 11501 USA Winthrop Univ Hosp, Div Nephrol, Mineola, NY 11501 USA Winthrop Univ HospMineola NY USA 11501 iv Nephrol, Mineola, NY 11501 USA Winthrop Univ Hosp, Dept Pathol, Mineola, NY 11501 USA Winthrop Univ HospMineola NY USA 11501 ept Pathol, Mineola, NY 11501 USA SUNY Stony Brook, Dept Med, Mineola, NY 11501 USA SUNY Stony Brook Mineola NY USA 11501 ok, Dept Med, Mineola, NY 11501 USA
Titolo Testata:
INFLAMMATION
fascicolo: 2, volume: 23, anno: 1999,
pagine: 191 - 205
SICI:
0360-3997(199904)23:2<191:MAFCIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ELECTROLYTE TRANSPORT; INFLAMMATORY BOWEL-DISEASE; ULCERATIVE-COLITIS; DESCENDING COLON; DISTAL COLON; RAT COLON; PROSTAGLANDINS; INVITRO; SULFASALAZINE; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Homaidan, FR AmerUSAiv Beirut, Dept Physiol, 850 3rd Ave,18th Floor, New York, NY 10022 Amer Univ Beirut 850 3rd Ave,18th Floor New York NY USA 10022
Citazione:
F.R. Homaidan et al., "Morphological and functional changes in the colonic epithelial cells in a rabbit model of colitis", INFLAMMATIO, 23(2), 1999, pp. 191-205

Abstract

A rabbit model of TNBS-colitis was used to study the effect of intestinal inflammation on epithelial cell function. Epithelial cells were isolated using a non-enzymatic isolation method without any apparent contamination with infiltrating immune cells. The isolated cells were found to be viable using dye exclusion studies, unidirectional Na+-fluxes, proliferation assays and morphological studies. The cells, however, showed morphological changes that suggested the presence of increased number of secretory vesicles. Thisincrease correlated well with the increase observed in ion and water secretion as measured by the short-circuit current. Finally, in the colitic tissue the number of PGE(2) receptors was greatly reduced with no changes observed in the affinity of PGE(2) to its receptor. The reduced number of PGE(2)receptors might be due to sensitization of the receptor. In conclusion, wehave demonstrated that morphologically and functionally normal epithelial cells can be isolated from the rabbit inflamed distal colon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 07:45:38