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Titolo:
Serum levels of ELAM-1, but not CD44, predict the clinical outcome of patients with preeclampsia
Autore:
Tempfer, C; Zeisler, H; Hefler, L; Schatten, C; Husslein, P; Kainz, C;
Indirizzi:
Univ Vienna, Sch Med, Dept Gynecol, Vienna, Austria Univ Vienna Vienna Austria enna, Sch Med, Dept Gynecol, Vienna, Austria Univ Vienna, Sch Med, Dept Obstet, Vienna, Austria Univ Vienna Vienna Austria ienna, Sch Med, Dept Obstet, Vienna, Austria
Titolo Testata:
HYPERTENSION IN PREGNANCY
fascicolo: 1, volume: 18, anno: 1999,
pagine: 45 - 55
SICI:
1064-1955(1999)18:1<45:SLOEBN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULES; UNITED-STATES; MATERNAL MORTALITY; PREGNANCY; IDENTIFICATION; FIBRONECTIN; EXPRESSION; RECEPTORS; ECLAMPSIA;
Keywords:
preeclampsia; adhesion molecules; prognosis; serum marker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Tempfer, C Univ Vienna, Sch Med, Dept Gynecol & Obstet, Wahringer Gurtel 18-20, A-1090 Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 -1090
Citazione:
C. Tempfer et al., "Serum levels of ELAM-1, but not CD44, predict the clinical outcome of patients with preeclampsia", HYPERTENS P, 18(1), 1999, pp. 45-55

Abstract

Objective: Preeclampsia is a severe complication in pregnancy, causing considerable maternal and fetal morbidity and mortality. Experimental evidenceindicates that adhesion molecules are key factors of endothelial activation in preeclampsia. The aim of our study was to evaluate if serum levels of adhesion molecules CD44 and ELAM-1 provide clinically useful information asprognostic markers for preeclampsia. Methods: A matched-pair study including 43 women with preeclampsia and 43 women with uncomplicated pregnancies was performed. Enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of CD44 and ELAM-1. Results were correlated with clinical data. Results: Median serum levels of ELAM-1 in controls and in women with preeclampsia were 8.9 ng/mL (minimum 0, maximum 20.0) and 12.0 ng/mL (minimum 4.0, maximum 27.0), respectively (Kruskal-Wallis test, p = 0.01). In a univariate logistic regression model, ELAM-1 did reveal a significant influence on the odds of presenting with preeclampsia as well as on the odds of premature termination of the pregnancy due to preeclampsia (univariate logistic regression, p = 0.03 and p = 0.01, respectively). The risk of premature termination of the pregnancy was 0.5%, 15.3%, and 80.5% at ELAM-1 serum levels of 0 ng/mL, 10 ng/mL, and 20 ng/mL, respectively. No significant correlation between CD44 serum levels and clinicopathological parameters due to preeclampsia was observed. Conclusions: Lf these results are confirmed in a larger series, ELAM-1 could be used as a prognostic factor in preeclamptic women, allowing early identification and appropriate management of high-risk patients with pre-eclampsia. It is unlikely that measurement of ELAM-1 will be of value as a screening test.

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Documento generato il 12/07/20 alle ore 06:34:34