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Titolo:
De novo programmed cell death in oral cancer
Autore:
Ravi, D; Ramadas, K; Mathew, BS; Nalinakumari, KR; Nair, MK; Pillai, MR;
Indirizzi:
Reg Canc Ctr, Div Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Div Radiat Oncol, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Div Dent Surg, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 3, volume: 34, anno: 1999,
pagine: 241 - 249
SICI:
0309-0167(199903)34:3<241:DNPCDI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR P53; REGULATORY P53; BCL-2 PROTEINS; APOPTOSIS; EXPRESSION; GENE; CARCINOMAS; FREQUENCY; PROSTATE; INDIA;
Keywords:
apoptosis; p53; bcl-2; bax; proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Pillai, MR Reg Canc Ctr, Div Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 ala, India
Citazione:
D. Ravi et al., "De novo programmed cell death in oral cancer", HISTOPATHOL, 34(3), 1999, pp. 241-249

Abstract

Aim: The importance of programmed cell death or apoptosis in the maintenance of tissue homoeostasis and the pathogenesis of oral cancer was analysed in relation to apoptosis regulatory proteins, tissue proliferation and tumour histology. Methods and results: The extent of apoptosis was defined by morphological criteria and the TUNEL (terminal deoxy nucleotidyl transferase-mediated dUTP biotin nick end labelling) assay p53, bar, bcl-2 and cyclin D1 expressionwas evaluated by immunocytochemistry. The presence of mutant p53 was analysed using a mutant p53-specific ELISA. An inverse correlation was observed between TUNEL reactivity and histology of the lesion (r = -0.555, P = 0.0001), There was also correlation between TUNEL reactivity and immunoreactivity of apoptosis regulatory proteins, p53 (r = 0.641. P = 0.00023), bcl-2 (r = -0.642, P = 0.00014) and bax (r = 0.651, P = 0.00002). The presence of mutant p53 protein showed an inverse correlation to the extent of apoptosis (r = -0.301, P = 0.00063). significant correlation was evident between the bax/bcl-2 ratio and TUNEL (r = 0.652, P = 0.00001) as well as between cyclinD1 and TUNEL reactivity (r = 0.577, P = 0.00001). Conclusions: results from this study suggest that apoptosis decreases as histological abnormality increases. Apoptotic regulatory proteins are also altered in a histologically dependent manner. Deregulated proliferation occurs simultaneously with decreased apoptosis during tumour progression in theoral mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:39:30