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Titolo:
Magnesium deficiency in adult rats promotes the induction of ventricular tachycardia by the administration of epinephrine
Autore:
Tomiyasu, T; Chishaki, A; Nakamura, M;
Indirizzi:
NakamuraJapanen Univ, Grad Sch Hlth & Nutr Sci, Jonan Ku, Fukuoka 8140104,Nakamura Gakuen Univ Fukuoka Japan 8140104 i, Jonan Ku, Fukuoka 8140104,
Titolo Testata:
HEART AND VESSELS
fascicolo: 3, volume: 13, anno: 1998,
pagine: 122 - 131
SICI:
0910-8327(1998)13:3<122:MDIARP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED CARDIAC-ARRHYTHMIAS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-ISCHEMIA; HYPOMAGNESEMIA; DEATH;
Keywords:
magnesium deficiency; epinephrine; sustained ventricular tachycardia; QT interval prolongation; sudden death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Chishaki, A KyushuaUniv, Sch Hlth Sci, Dept Nursing, Higashi Ku, 3-1-1 Maidashi, Fukuok Kyushu Univ 3-1-1 Maidashi Fukuoka Japan 8128582 ashi, Fukuok
Citazione:
T. Tomiyasu et al., "Magnesium deficiency in adult rats promotes the induction of ventricular tachycardia by the administration of epinephrine", HEART VESS, 13(3), 1998, pp. 122-131

Abstract

The effects of magnesium deficiency on epinephrine-induced ventricular tachyarrhythmia were investigated in adult rats. Forty-two adult Wistar rats were fed a magnesium-deficient diet while 30 rats were fed a standard diet for 20 days. The plasma magnesium concentration was lower in the magnesium-deficient rats (0.22 +/- 0.01 mmol/l) than in the control rats (0.76 +/- 0.03 mmol/l, P < 0.001). Using a telemetry system, electrocardiograms and arterial blood pressure were recorded on a polygraph in an unrestrained condition. Epinephrine was infused intravenously starting at 5 mu g/kg per minute. The QT interval was prolonged to 50 +/- 1 ms in the magnesium-deficient rats compared with 44 +/- 1 ms in the control rats (P < 0.001). Before the administration of epinephrine, no ventricular tachyarrhythmias or seizures were found in either the control or the magnesium-deficient rats. The incidence of epinephrine-induced sustained ventricular tachycardia (VT) was higherin the magnesium-deficient rats (86%) than in the control rats (43%, P < 0.01). However, this VT did not result in sudden death. Seizures always preceded death in both the magnesium-deficient and control rats while the arrhythmias observed immediately before death were mainly bradyarrhythmias. The present study in an adult rat magnesium-deficient model revealed that magnesium deficiency enhances the susceptibility to epinephrine-induced ventricular tachyarrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:31:51