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Titolo:
P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death
Autore:
Ferrari, D; Los, M; Bauer, MKA; Vandenabeele, P; Wesselborg, S; Schulze-Osthoff, K;
Indirizzi:
Univ Tubingen, Med Clin, Dept Internal Med 1, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 Med 1, D-72076 Tubingen, Germany Flanders Interuniv Inst Biotechnol, Dept Mol Biol, Ghent, Belgium FlandersInteruniv Inst Biotechnol Ghent Belgium l Biol, Ghent, Belgium
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 447, anno: 1999,
pagine: 71 - 75
SICI:
0014-5793(19990319)447:1<71:PPLIAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ATP; THYMOCYTE APOPTOSIS; RECEPTOR; PROTEASOME; IL-1-BETA; RELEASE; P2X(7); FLICE;
Keywords:
apoptosis; ATP; caspase; necrosis; P2Z; purinoreceptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze-Osthoff, K Univ6Tubingen, Med Clin, Dept Internal Med 1, Otfried Muller Str 10, D-7207 Univ Tubingen Otfried Muller Str 10 Tubingen Germany D-72076
Citazione:
D. Ferrari et al., "P2Z purinoreceptor ligation induces activation of caspases with distinct roles in apoptotic and necrotic alterations of cell death", FEBS LETTER, 447(1), 1999, pp. 71-75

Abstract

Myeloic cells express a peculiar surface receptor for extracellular ATP, called the P2Z/P2X(7) purinoreceptor, which is involved in cell death signalling. Here, we investigated the role of caspases, a family of proteases implicated in apoptosis and the cytokine secretion. We observed that extracellular ATP induced the activation of multiple caspases including caspase-1, -3 and -8, and subsequent cleavage of the caspase substrates PARP and Iamin B. Using caspase inhibitors, it was found that caspases were specifically involved in ATP-induced apoptotic damage such as chromatin condensation and DNA fragmentation, In contrast, inhibition of caspases only marginally affected necrotic alterations and cell death proceeded normally whether or not nuclear damage was blocked. Our results therefore suggest that the activation of caspases by the P2Z receptor is required for apoptotic but not necrotic alterations of ATP-induced cell death. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:19:09