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Titolo:
Carotenoids inhibit DNA synthesis in human aortic smooth muscle cells
Autore:
Carpenter, KLH; Hardwick, SJ; Albarani, V; Mitchinson, MJ;
Indirizzi:
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 447, anno: 1999,
pagine: 17 - 20
SICI:
0014-5793(19990319)447:1<17:CIDSIH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTIONAL COMMUNICATION; BETA-CAROTENE; PROLIFERATION; CANCER; GROWTH; ATHEROSCLEROSIS; ANTIOXIDANTS; TOCOPHEROLS; MACROPHAGES; EXPRESSION;
Keywords:
carotenoid; lycopene; beta-carotene; DNA synthesis; smooth muscle cell (human aortic); atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Carpenter, KLH Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB21QP, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP d
Citazione:
K.L.H. Carpenter et al., "Carotenoids inhibit DNA synthesis in human aortic smooth muscle cells", FEBS LETTER, 447(1), 1999, pp. 17-20

Abstract

Quiescent, serum-starved human aortic smooth muscle cells were restimulated with 20% foetal calf serum in Dulbecco's modified Eagle medium, in the presence and absence of p-carotene, canthaxanthin, zeaxanthin, lycopene, lutein or beta-cryptoxanthin, at final concentrations up to 23 mu M. Concentration-dependent inhibition of DIVA synthesis, measured by [methyl-H-3]thymidine incorporation, was observed for the carotenoids, except for canthaxanthin and lutein which had no effect. Lycopene was the most potent of the carotenoids tested. The results suggest that antiproliferative effects of dietary carotenoids might be of significance in vivo. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:25:54