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Titolo:
A comparative study of the rifampicin binding and elution characteristics for collagen- and albumin-sealed vascular grafts
Autore:
Lovering, AM; MacGowan, AP;
Indirizzi:
Southmeadluat,Hosp, Dept Med Microbiol, Bristol Ctr Antimicrobial Res & Eva Southmead Gen Hosp Bristol Avon England BS10 5NB Antimicrobial Res & Eva
Titolo Testata:
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
fascicolo: 4, volume: 17, anno: 1999,
pagine: 347 - 350
SICI:
1078-5884(199904)17:4<347:ACSOTR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISTAPHYLOCOCCAL ACTIVITY; RELEASE SYSTEM; DACRON GRAFT; INFECTION;
Keywords:
vascular prosthesis; dacron; rifampicin; graft-soaking;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lovering, AM Southmeadluat,Hosp, Dept Med Microbiol, Bristol Ctr Antimicrobial Res & Eva Southmead Gen Hosp Bristol Avon England BS10 5NB l Res & Eva
Citazione:
A.M. Lovering e A.P. MacGowan, "A comparative study of the rifampicin binding and elution characteristics for collagen- and albumin-sealed vascular grafts", EUR J VAS E, 17(4), 1999, pp. 347-350

Abstract

Objectives: to assess the rifampicin binding and elution characteristics for three protein-sealed vascular grafts. Design: in vitro study. Materials: Cardial and Hemashield collagen-sealed and the DeBakey/Vasculour albumin-sealed vascular grafts. Methods: the grafts were soaked in a 60 000 mg/l solution of rifampicin at 37 degrees C for 15 min. Bound drug was eluted from the grafts at 37 degrees C and at timed intervals the concentrations of rifampicin remaining in the grafts were determined. Results: although all three grafts contained high concentrations of rifampicin immediately after soaking these rapidly fell on washing and only a small fraction of the adsorbed rifampicin was rightly bound to the grafts. Rifampicin loading of this tightly bound fraction was similar for the two collagen-sealed grafts (1.7-2.0 mg/kg) but higher for the albumin-sealed graft (16.0 mg/kg). Elution of the tightly bound fraction appeared to follow first-order kinetics with elimination half-lives of 89-141 h. The concentrations of rifampicin remaining in the grafts after eight days were above those needed to inhibit sensitive staphylococci and were 0.7 mg/kg (collagen-sealed grafts) to 3.7 mg/kg (albumin-sealed graft). Conclusions: there is broad equivalence between the rifampicin binding andelution for the two collagen-sealed grafts, but there appears to be slightly higher binding for the albumin-sealed graft.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:30:44