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Titolo:
Could testicular descent in humans be promoted by direct androgen stimulation of the gubernaculum testis?
Autore:
Hosie, S; Wessel, L; Waag, KL;
Indirizzi:
Univ8167delberg, Klinikum Mannheim, Med Fac Mannheim, Dept Pediat Surg, D-6 Univ Heidelberg Mannheim Germany D-68167 Mannheim, Dept Pediat Surg, D-6
Titolo Testata:
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
fascicolo: 1, volume: 9, anno: 1999,
pagine: 37 - 41
SICI:
0939-7248(199902)9:1<37:CTDIHB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG FETUS; RECEPTOR;
Keywords:
testicular descent; gubernaculum; androgens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hosie, S Univin,idelberg, Klinikum Mannheim, Fak Klin Med Mannheim, Kinderchirurg Kl Univ Heidelberg Theodor Kutzer Ufer Mannheim Germany D-68167 Kl
Citazione:
S. Hosie et al., "Could testicular descent in humans be promoted by direct androgen stimulation of the gubernaculum testis?", EUR J PED S, 9(1), 1999, pp. 37-41

Abstract

Gubernaculum testis and androgens play an important role in physiologic testicular descent. A direct androgen stimulation of the gubernaculum is onlypossible in the presence of specific receptors, which have not yet been demonstrated. We have determined the androgen-binding capacity in 61 samples of gubernaculum testis from 48 patients, 34 samples belonging to patients with maldescended testes. In 43 out of 61 instances we found androgen binding with values up to 72 fmol/mg, with a mean of 13.08 fmol/mg. In 27 samples from patients with a deep scrotal positioned gonad the mean androgen-binding capacitywas 18.74 fmol/mg. In 10 samples from patients with a gonad in the proximal scrotum and 19 patients with epifascial ectopy or a low inguinal positionthe mean androgen-binding capacities decreased progressively to 9 fmol/mg and 5.95 fmol/mg. In the 5 samples from patients with high inguinal or abdominal testes the binding capacity of 17.8 fmol/mg did not significantly differ from the value obtained in the samples of the normal-positioned gonads,suggesting that transabdominal descent is probably not androgen-dependent. We divided the probes into receptor status positive for a binding capacityhigher than or equal to 10 fmol/mg, and receptor status negative for a binding capacity under 10 fmol/mg. 63 % of the samples from patients with scrotal positioned testes were receptor status positive, 85 % of the samples belonging to patients with maldescended testes were receptor status negative. Receptor status was negative in patients with high scrotal, epifascial or low inguinal and high inguinal or abdominal testes in 90 %, 95 % and 40 % of the samples respectively. Immunohistochemical examination of 10 samples showed small cell groups with stained nuclei in 2 out of 5 patients with normal-positioned testes. All other samples were negative. These findings prove that hormone binding was accomplished by specific intranuclear receptors. These findings allow for the first time the hypothesis of a direct androgen stimulation of the human gubernaculum testis. The probable mechanism is an increase in mucopolysaccharides leading to a swelling of the gubernaculum, dilating the inguinal canal and promoting testicular descent. Although certainly a multifactorial process, quality and quantity of androgen receptors would influence the extent of transinguinal testicular descent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:11:46