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Titolo:
Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens
Autore:
Dalley, JW; Thomas, KL; Howes, SR; Tsai, TH; Aparicio-Legarza, MI; Reynolds, GP; Everitt, BJ; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2TN S Yorkshire, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 4, volume: 11, anno: 1999,
pagine: 1265 - 1274
SICI:
0953-816X(199904)11:4<1265:EOELOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; EARLY GENE-EXPRESSION; D-ASPARTATE BINDING; STRIATAL DOPAMINE; MESSENGER-RNA; BEHAVIORAL SENSITIZATION; INDUCED HYPERACTIVITY; CORTICAL EFFERENTS; LOCOMOTOR-ACTIVITY; SOMATOSTATIN GENE;
Keywords:
amphetamine; glutamate; in vivo microdialysis; locomotor activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Dalley, JW Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB B, England
Citazione:
J.W. Dalley et al., "Effects of excitotoxic lesions of the rat prefrontal cortex on CREB regulation and presynaptic markers of dopamine and amino acid function in the nucleus accumbens", EUR J NEURO, 11(4), 1999, pp. 1265-1274

Abstract

The present study investigated the effects of excitotoxic lesions of the prefrontal cortex (PFC) on dopamine (DA) and excitatory amino acid (EAA) function in the nucleus accumbens core using in vivo microdialysis in freely moving rats. As a postsynaptic marker of neuronal function, the nuclear levels of the transcriptional factor CREB and its active phosphorylated form, CREB-P, were measured in the ventral tegmental area (VTA), and in the core and shell subregions of the nucleus accumbens of sham and lesioned animals. PFC-lesioned animals exhibited a greater locomotor response to novelty and amphetamine administration (125-500 mu g/kg i.v.). No change was observed in extracellular levels of glutamate or saturable D-aspartate binding (a marker for the high-affinity EAA transporter) in the nucleus accumbens of PFC-lesioned animals. Extracellular levels of DA were comparable in sham and lesioned animals under tonic conditions, however, following amphetamine administration, DA efflux was significantly attenuated in lesioned animals. No correlation was observed between microdialysate levels of amino acids and the attenuated dopaminergic response to amphetamine in lesioned animals. Further, no effect of the lesion was found on nuclear CREB protein in saline- and amphetamine-treated rats. The density of CREB-P immunoreactive nuclei, while remaining unchanged in the VTA, increased in the nucleus accumbens shell following amphetamine treatment in lesioned animals. The results show that an important modulatory role of the PFC on the behavioural response to novelty and amphetamine is associated with the level of immediate-early generegulation rather than levels of extracellular DA and amino acids in the ventral striatum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:33:37