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Titolo:
Effects of general anaesthetic procedures on mitochondrial function of human skeletal muscle
Autore:
Miro, O; Barrientos, A; Alonso, JR; Casademont, J; Jarreta, D; Urbano-Marquez, A; Cardellach, F;
Indirizzi:
Univmedrcelona, Hosp Clin,Med Sch,Dept Internal Med, August Pi & Sunyer Bio Univ Barcelona Barcelona Spain E-08036 ernal Med, August Pi & Sunyer Bio
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 1, volume: 55, anno: 1999,
pagine: 35 - 41
SICI:
0031-6970(199903)55:1<35:EOGAPO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER MITOCHONDRIA; OXIDATIVE-PHOSPHORYLATION; CHAIN ACTIVITIES; RESPIRATION; ANESTHETICS; INHIBITION; DEPRESSION; MECHANISMS; HALOTHANE; MEMBRANES;
Keywords:
general anaesthetics; halothane; isoflurane; mitochondria; electron transport chain; respiratory chain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Cardellach, F Univmedrcelona,painp Clin,Med Sch,Dept Internal Med, August Pi & Sunyer Bio Univ Barcelona Villarroel 170 Barcelona Spain E-08036 r Bio
Citazione:
O. Miro et al., "Effects of general anaesthetic procedures on mitochondrial function of human skeletal muscle", EUR J CL PH, 55(1), 1999, pp. 35-41

Abstract

Background: General anaesthetics inhibit mitochondrial function in animal models. However, very few studies have been performed in humans, and the results have not been conclusive. Methods: We prospectively studied the oxygen consumption and the individual enzyme activity of each complex of the mitochondrial respiratory chain ofskeletal muscle mitochondria in 54 healthy individuals who underwent general anaesthesia for orthopaedic surgery. The control group (n = 54) was madeup of individuals submitted to the same orthopaedic procedure under regional anaesthesia (n = 31), and patients who underwent muscle biopsies for diagnostic purposes by local anaesthesia (n = 23). Results: We found a significant decrease in the oxidation of glutamate (-36%), succinate (-25%) and ascorbate (-29%) in the general anaesthetic groupcompared with the controls (P < 0.001 for all substrates). The level of such inhibition was similar for volatile anaesthetics with strong (halothane)or weak (isoflurane) negative inotropic effect. By contrast, the enzymaticactivity of all individual complexes and the coupling of oxidative phosphorylation did not differ between the two groups. Conclusion: We conclude that during general anaesthetic procedures there is an extensive inhibition of substrate oxidation in human muscle mitochondria, and that it is not caused by a direct effect on complexes of the mitochondrial respiratory chain or through uncoupling oxidative phosphorylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:14:43