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Titolo:
RELEASE OF 4-HYDROXYNONENAL, AN ALDEHYDIC MEDIATOR OF INFLAMMATION, DURING POSTISCHEMIC REPERFUSION OF THE MYOCARDIUM
Autore:
GRUNE T; SIEMS WG; SCHONHEIT K; BLASIG IE;
Indirizzi:
HERZOG JULIUS HOSP D-38655 BAD HARZBURG GERMANY HERZOG JULIUS HOSP D-38655 BAD HARZBURG GERMANY HUMBOLDT UNIV BERLIN,MED FAC CHARITE,PHYS MED CLIN D-10098 BERLIN GERMANY HUMBOLDT UNIV BERLIN,MED FAC CHARITE,REHABIL CLIN D-10098 BERLIN GERMANY RES INST MOLEC PHARMACOL W-1136 BERLIN GERMANY
Titolo Testata:
International journal on tissue reactions
fascicolo: 4, volume: 15, anno: 1993,
pagine: 145 - 150
SICI:
0250-0868(1993)15:4<145:RO4AAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-SPIN-RESONANCE; FREE-RADICALS; POSTISCHEMIC REPERFUSION; THIOBARBITURIC ACID; LIPID-PEROXIDATION; XANTHINE-OXIDASE; INJURY; HEART; MALONDIALDEHYDE; SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Grune et al., "RELEASE OF 4-HYDROXYNONENAL, AN ALDEHYDIC MEDIATOR OF INFLAMMATION, DURING POSTISCHEMIC REPERFUSION OF THE MYOCARDIUM", International journal on tissue reactions, 15(4), 1993, pp. 145-150

Abstract

For the first time it was demonstrated that 4-hydroxynonenal (HNE) isformed by the myocardium. 1 to 2pmol HNE/min/mg protein were releasedfrom isolated perfused hearts of 18-month-old WKY rats during a normoxic period of perfusion. During the first minutes of reperfusion following 30 min of ischaemia, the mean value of HNE release increased in comparison to preischaemic HNE release (preischaemic control). However,the alterations were significant only in the second minute of reperfusion. HNE liberation significantly intensified during the early reperfusion period of hearts of 18-month-old spontaneously hypertensive rats(SHR, with cardiac hypertrophy and congestive heart failure) in comarison with the preischaemic control period. Furthermore, HNE liberationfrom those hearts was higher than from hearts of normotensive controlanimals (WKY rats). Maximum quantities were observed 2 min after ischaemia, with 6 to 10pmol HNE/min/mg protein. The results suggest that the formation of chemotactic products of radical-induced lipid peroxidation, such as HNE, is markedly increased in reperfused hypertrophic and failing myocardium, and emphasize the role of HNE as a possible chemotactic agent during postischaemic reoxygenation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:27:09