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Titolo:
Male infertility: Possible association with valproate exposure
Autore:
Yerby, MS; McCoy, GB;
Indirizzi:
N Pacific Epi1epsy Res, Portland, OR 97210 USA N Pacific Epi1epsy Res Portland OR USA 97210 Res, Portland, OR 97210 USA Urol Clin, Portland, OR USA Urol Clin Portland OR USAUrol Clin, Portland, OR USA
Titolo Testata:
EPILEPSIA
fascicolo: 4, volume: 40, anno: 1999,
pagine: 520 - 521
SICI:
0013-9580(199904)40:4<520:MIPAWV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRODUCTIVE ENDOCRINE DISORDERS; EPILEPSY; WOMEN;
Keywords:
valproate; infertility; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Yerby, MS N Pacific Epi1epsy Res, 2455 NW Marshall,Suite 14, Portland, OR 97210 USA N Pacific Epi1epsy Res 2455 NW Marshall,Suite 14 Portland OR USA 97210
Citazione:
M.S. Yerby e G.B. McCoy, "Male infertility: Possible association with valproate exposure", EPILEPSIA, 40(4), 1999, pp. 520-521

Abstract

Purpose: To describe a potential association between male infertility and valproate (VPA) exposure. VPA has been implicated in the development of polycystic ovarian disease and subsequent menstrual and infertility problems in women with epilepsy. Infertility has been well described in population-based studies of persons with epilepsy. The low marital rates for men with epilepsy have previously been thought to play a major contributing role. Methods: We report a case of a 32-year-old man whose wife and he were ableto bear a child before the development of his epilepsy. With VPA monotherapy, the family were unable to conceive despite 3 years of unprotected intercourse. An infertility evaluation of the man revealed a very low sperm count of <50,000/ml, no motile sperm, <10% viability, and 100% with abnormal structure. Follicle-stimulating hormone, luteinizing hormone, and testosterone levels were normal. Results: Felbamate (FBM) was initiated and VPA discontinued for improved seizure control. Within 4 months, the couple conceived their second child. Aseminal analysis revealed a sperm count of >16 million, 50% motility, 78% viability, and 72% with abnormal structure. Conclusions: One must be cautious in extrapolating from a case report, butthese findings strongly suggest a direct effect of VPA on spermatic structure and function.

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Documento generato il 04/07/20 alle ore 14:24:25