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Titolo:
Selective proteasome inhibitors: modulators of antigen presentation?
Autore:
Groettrup, M; Schmidtke, G;
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 2, volume: 4, anno: 1999,
pagine: 63 - 71
SICI:
1359-6446(199902)4:2<63:SPIMOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; MULTICATALYTIC PROTEINASE COMPLEX; MAJOR-HISTOCOMPATIBILITY-COMPLEX; LACTACYSTIN BETA-LACTONE; INTERFERON-GAMMA; 20S PROTEASOME; ENCODED SUBUNITS; PEPTIDASE ACTIVITIES; REGULATOR PA28; ACTIVATOR PA28;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Groettrup, M Cantonal Hosp St Gall, Dept Res, Bldg 09, CH-9007 St Gallen, Switzerland Cantonal Hosp St Gall Bldg 09 St Gallen Switzerland CH-9007
Citazione:
M. Groettrup e G. Schmidtke, "Selective proteasome inhibitors: modulators of antigen presentation?", DRUG DISC T, 4(2), 1999, pp. 63-71

Abstract

The proteasome is the main nonlysosomal endoprotease in the cytoplasm and nucleus of all eukaryotic cells. It is responsible for the generation of most antigenic peptides as ligands for major histocompatibility complex (MHC)class I proteins. The proteasome hence qualifies as a target for modifyingor silencing antigen processing and presentation to cytotoxic T cells, which are important players in transplant rejection and autoimmune disease. The authors summarize recent progress in the understanding of antigen processing by the proteasome and discuss the potential of novel and selective proteasome inhibitors as drugs for suppressing or modifying the cytotoxic immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:58:08