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Titolo:
Mitochondrial pathology in Parkinson's disease and implications for therapeutic intervention
Autore:
Swerdlow, RH; Parker, WD;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 1, volume: 46, anno: 1999,
pagine: 44 - 50
SICI:
0272-4391(199901)46:1<44:MPIPDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-TRANSPORT CHAIN; COMPLEX-I DEFECT; RESPIRATORY-CHAIN; HUNTINGTONS-DISEASE; SUBSTANTIA-NIGRA; SKELETAL-MUSCLE; UBIQUINONE OXIDOREDUCTASE; MATERNAL INHERITANCE; BRAIN MITOCHONDRIA; DNA;
Keywords:
mitochondria; Parkinson's disease; mitochondrial DNA; therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, RH Univ8Virginia, Hlth Sci Ctr, Dept Neurol, Box 394, Charlottesville, VA 2290 Univ Virginia Box 394 Charlottesville VA USA 22908 e, VA 2290
Citazione:
R.H. Swerdlow e W.D. Parker, "Mitochondrial pathology in Parkinson's disease and implications for therapeutic intervention", DRUG DEV R, 46(1), 1999, pp. 44-50

Abstract

Although the ultimate origin and role of mitochondrial pathology in Parkinson's disease (PD) remains controversial, accumulating data suggest that mitochondrial dysfunction is genetic and plays an important role in neurodegeneration. PD mitochondria display abnormal electron transport chain activity, increased reactive oxygen species generation, and abnormal calcium handling. These abnormalities arise, at least in part, from information encoded by mitochondrial DNA. These processes are implicated in current models of neuronal death and validate ongoing efforts to develop mitochondrial-level pharmacologic interventions for the treatment of this disease. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 20:57:29