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Titolo:
MAGNETIC-RESONANCE ABNORMALITIES AND CARDIOVASCULAR-DISEASE IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY
Autore:
MANOLIO TA; KRONMAL RA; BURKE GL; POIRIER V; OLEARY DH; GARDIN JM; FRIED LP; STEINBERG EP; BRYAN RN; CODY ME; CRUISE RG; ETTINGER WH; FURBERG CD; HEISS G; KLOPFENSTEIN HS; LEFKOWITZ DS; LYLES MF; MITTELMARK MB; TELL GS; BOMMER W; LEE M; ROBBINS J; SCHENKER M; KUMANYIKA S; BUSH TL; CHABOT J; COMSTOCK GW; GERMAN PS; HILL J; KITTNER SJ; POWE NR; PRICE TR; ROCK R; SZKLO M; BONK J; KULLER LH; MCLAUGHLIN B; MEYER P; NEWMAN A; ORCHARD TJ; RUTAN GH; SCHULZ R; SMITH VE; WOLFSON SK; ANTONCULVER H; KNOLL M; KUROSAKI T; WONG N; POLAK JF; POTTER J; BOVILL E; CORNELL E; HOWARD P; TRACY RP; ENRIGHT P; TOOGOOD S; CALHOUN K; CALHOUN H; MONTAGUE P; RAUTAHARJU F; RAUTAHARJU P; FELLOWS D; HOLTZ P; KRAUT M; LEE G; MILLER TJ; SCHERTZ L; WILKINS L; YUE N; BORHANI NO; FITZPATRICK AL; HERMANSON BK; PSATY BM; SISCOVICK DS; SHEMANSKI L; WAHL PW; BILD DE; SAVAGE PJ; SMITH P;
Indirizzi:
NHLBI,DIV EPIDEMIOL & CLIN APPLICAT,FED BLDG,RM 301,7550 WISCONSIN AVE BETHESDA MD 20892 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 UNIV CALIF DAVIS,DEPT RADIOL SACRAMENTO CA 00000 GEISINGER CLIN & MED CTR,DEPT RADIOL DANVILLE PA 00000 UNIV CALIF IRVINE,DEPT MED ORANGE CA 00000 JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL BALTIMORE MD 21205 UNIV PITTSBURGH PITTSBURGH PA 00000 UNIV CALIF IRVINE,CTR ECHOCARDIOG READING IRVINE CA 00000 GEISINGER MED CLIN,CTR ULTRASOUND READING DANVILLE PA 00000 UNIV VERMONT,CENT BLOOD ANAL LAB BURLINGTON VT 00000 NHLBI,PROJECT OFF BETHESDA MD 00000 MAYO CLIN & MAYO FDN,CTR PULM FUNCT READING ROCHESTER MN 00000 UNIV ALBERTA,CTR ELECTROCARDIOG READING EDMONTON AB CANADA JOHNS HOPKINS UNIV,CTR MAGNET RESONANCE IMAGING READING BALTIMORE MD 00000 UNIV WASHINGTON,CTR COORDINATING SEATTLE WA 00000
Titolo Testata:
Stroke
fascicolo: 2, volume: 25, anno: 1994,
pagine: 318 - 327
SICI:
0039-2499(1994)25:2<318:MAACIO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CEREBROVASCULAR RISK-FACTORS; WHITE-MATTER; COMPUTED-TOMOGRAPHY; BRAIN ATROPHY; AGING BRAIN; AGE; LESIONS; VOLUME; ATHEROSCLEROSIS;
Keywords:
EPIDEMIOLOGY; LEUKOENCEPHALOPATHY; MAGNETIC RESONANCE IMAGING; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Manolio et al., "MAGNETIC-RESONANCE ABNORMALITIES AND CARDIOVASCULAR-DISEASE IN OLDER ADULTS - THE CARDIOVASCULAR HEALTH STUDY", Stroke, 25(2), 1994, pp. 318-327

Abstract

Background and Purpose Cerebral magnetic resonance imaging often detects abnormalities whose significance is unknown. The prevalence and correlates of findings such as ventricular enlargement, sulcal widening,and increased white matter signal intensity were examined in 303 men and women aged 65 to 95 years participating in a multicenter study of cardiovascular disease. Methods Cerebral magnetic resonance imaging was performed and interpreted according to a standard protocol, and findings were correlated with measures of cardiovascular disease and its risk factors. Results Measures of cerebral atrophy increased with age and were greater in men than in women (each P<.01). Ventricular enlargement and sulcal widening were associated with prior stroke, hypertension, diabetes, and white race (each P<.03). Extent of white matter hyperintensity was associated with age, prior stroke, hypertension, and use of diuretics (each P<.004). On multivariate analysis, age, male gender, white race, and prior stroke retained strong associations with increased ventricular and sulcal scores. After adjustment for age, prior stroke, and other risk factors, white matter hyperintensity was associated with atherosclerosis as measured by increased internal carotid artery thickness on ultrasound. Conclusions Cerebral atrophy and white matter hyperintensity are common in the elderly and are associated withage, prior stroke, and known cardiovascular risk factors. Though these findings have been suggested to represent normal aging, their wide variability and associations with cardiovascular disease argue against their inevitability with advancing age and support the need to identify modifiable risk factors for these abnormalities.

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Documento generato il 05/12/20 alle ore 16:50:42