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Titolo:
Attenuated severity of new acute ischemic events in patients with previouscoronary heart disease receiving long-acting nitrates
Autore:
Garcia-Dorado, D; Permanyer-Miralda, G; Brotons, C; Calvo, F; Camprecios, M; Oliveras, J; Santos, MT; Moral, I; Soler-Soler, J;
Indirizzi:
Hosp Gen Valle Hebron, Serv Cardiol, Barcelona 08035, Spain Hosp Gen ValleHebron Barcelona Spain 08035 diol, Barcelona 08035, Spain
Titolo Testata:
CLINICAL CARDIOLOGY
fascicolo: 4, volume: 22, anno: 1999,
pagine: 303 - 308
SICI:
0160-9289(199904)22:4<303:ASONAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
STABLE ANGINA-PECTORIS; ORGANIC NITRATES; TRANSDERMAL NITROGLYCERIN; THROMBUS FORMATION; UNSTABLE ANGINA; ANTIPLATELET; INHIBITION; ASPIRIN; ARTERIES;
Keywords:
long-acting nitrates; unstable angina; myocardial infarction; aspirin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Dorado, D Hosp5,en Valle Hebron, Serv Cardiol, Pf Vall Hebron 119-129, Barcelona 0803 Hosp Gen Valle Hebron Pf Vall Hebron 119-129 Barcelona Spain 08035
Citazione:
D. Garcia-Dorado et al., "Attenuated severity of new acute ischemic events in patients with previouscoronary heart disease receiving long-acting nitrates", CLIN CARD, 22(4), 1999, pp. 303-308

Abstract

Background: Platelet aggregation and secondary vasoconstriction are key events in the genesis of acute coronary syndromes. Hypothesis: Since nitrates have vasodilatory and antiaggregant effects, treatment with long-acting nitrates at the time of onset of acute coronary syndromes could be associated with attenuation of their severity. Methods: A consecutive series of 533 patients with acute coronary syndromeand past history of coronary artery disease admitted to the Cardiology Service of a general hospital was studied. A specific questionnaire assessed the use of nitrates and other relevant drugs, as well as other clinical variables. The diagnosis of unstable angina or acute myocardial infarction (MI)was established according to clinical, electrocardiographic, and enzymaticcriteria. Results: In the whole cohort, 169 patients had MI and 364 had unstable angina. Previous use of long-acting nitrates was significantly more common in patients with unstable angina (56%) than in those with MI (37%) (p < 0.0001). Multivariate analysis identified being a nonsmoker [odds ratio: 95%, confidence limits (CL) 0.37, 0.23-0.59], previous unstable angina (CL 0.62, 0.41-0.92), use of aspirin (CL 0.58, 0.41-0.92), and use of long-acting nitrates (CL 0.61, 0.4-0.93) as the independent predictors of the development ofunstable angina rather than MI; of these the combination of nitrates and aspirin was the strongest predictor. Conclusions: Long-acting nitrates as well as aspirin are suggested to havea protective or modifying effect on the development of acute coronary syndromes, favoring unstable angina rather than acute MI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:40:29