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Titolo:
Coronary flow reserve in young men with familial combined hyperlipidemia
Autore:
Pitkanen, OP; Nuutila, P; Raitakari, OT; Porkka, K; Iida, H; Nuotio, I; Ronnemaa, T; Viikari, J; Taskinen, MR; Ehnholm, C; Knuuti, J;
Indirizzi:
Turku Univ, Dept Med, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Med, Turku, Finland Turku Univ, Dept Clin Physiol, Turku, Finland Turku Univ Turku FinlandTurku Univ, Dept Clin Physiol, Turku, Finland Turku Univ, Turku PET Ctr, Turku, Finland Turku Univ Turku FinlandTurku Univ, Turku PET Ctr, Turku, Finland Natl Publ Hlth Inst, Helsinki, Finland Natl Publ Hlth Inst Helsinki Finland Publ Hlth Inst, Helsinki, Finland Univ Helsinki, Dept Med, Helsinki, Finland Univ Helsinki Helsinki Finland iv Helsinki, Dept Med, Helsinki, Finland Res Inst Brain & Blood Vessels Akita, Akita, Japan Res Inst Brain & Blood Vessels Akita Akita Japan ls Akita, Akita, Japan
Titolo Testata:
CIRCULATION
fascicolo: 13, volume: 99, anno: 1999,
pagine: 1678 - 1684
SICI:
0009-7322(19990406)99:13<1678:CFRIYM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION TOMOGRAPHY; MYOCARDIAL BLOOD-FLOW; APOLIPOPROTEIN-B GENE; HEART-DISEASE; ARTERY DISEASE; N-13 AMMONIA; NONINVASIVE QUANTIFICATION; LIPID-LEVELS; LPL GENE; LIPOPROTEINS;
Keywords:
lipids; blood flow; myocardium; hyperlipidemia, familial combined; tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Knuuti, J Turku Univ, Cent Hosp, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland Turku Univ POB 52 Turku Finland FIN-20521 -20521 Turku, Finland
Citazione:
O.P. Pitkanen et al., "Coronary flow reserve in young men with familial combined hyperlipidemia", CIRCULATION, 99(13), 1999, pp. 1678-1684

Abstract

Background-Familial combined hyperlipidemia (FCHL) is a common hereditary disorder of lipoprotein metabolism estimated to cause 10% to 20% of premature coronary heart disease. We investigated whether functional abnormalitiesexist in coronary reactivity in asymptomatic patients with FCHL. Methods and Results-We studied 21 male FCHL patients (age, 34.8+/-5.4 years) and a matched group of 21 healthy control subjects. Myocardial blood flow (MBF) was measured at baseline and during dipyridamole-induced hyperemia with PET and O-15-labeled water. The baseline MBF was similar in patients and control subjects (0.79+/-0.19 versus 0.88+/-0.20 mL.g(-1).min(-1), P=NS). An increase in MBF was seen in both groups after dipyridamole infusion, but MBF at maximal vasodilation was lower in FCHL patients (3.54+/-1.59 versus 4.54+/-1.17 mL.g(-1).min(-1), P=0.025). The difference in coronary flow reserve (CFR) was not statistically significant (4.7+/-2.2 versus 5.3+/-1.6, P=NS, patients versus control subjects). Considerable variability in CFR values-was detected within the FCHL group. Patients with phenotype IIB (n=8) bad lower now during hyperemia (2.5+/-1.2versus 4.2+/-1.5 mL.g(-1).min(-1), P<0.05) and lower CFR (3.4+/-2.1 versus 5.4+/-2.0, P<0.05) compared withphenotype IIA (n=13). Conclusions-Abnormalities in coronary flow regulation exist in young asymptomatic FCHL patients expressing phenotype IIB (characterized by abnormalities in both serum cholesterol and triglyceride concentrations). This is in line with previous observations suggesting that the metabolic abnormalitiesrelated to the pathophysiology of FCHL are associated with the phenotypes IIB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:19:18