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Titolo:
Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies
Autore:
Parrado, A; West, R; Jordan, D; Bastard, C; McKenna, S; Whittaker, JA; Bentley, P; White, D; Chomienne, C; Padua, RA;
Indirizzi:
Univopoiet, Hop St Louis, Inst Hematol, Ctr Hayem,Lab Biol Cellulaire Hemat Univ Paris Paris France F-75010 tol, Ctr Hayem,Lab Biol Cellulaire Hemat Univ Wales Coll Med, Dept Haematol, Cardiff CF4 4XN, S Glam, Wales Univ Wales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Etab Tranfus Sanguine & Genet Humaine Haute Norma, Rouen, France Etab Tranfus Sanguine & Genet Humaine Haute Norma Rouen France , France Llandough Hosp, Cardiff, S Glam, Wales Llandough Hosp Cardiff S Glam Wales andough Hosp, Cardiff, S Glam, Wales
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 104, anno: 1999,
pagine: 738 - 741
SICI:
0007-1048(199903)104:4<738:AOTRAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; TRANSLOCATION; VARIANT; FUSION;
Keywords:
retinoic acid receptor alpha; myelodysplastic syndromes; acute myeloid leukaemia; B-chronic lymphocytic leukaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Parrado, A Univopoiet, Hop St Louis, Inst Hematol, Ctr Hayem,Lab Biol Cellulaire Hemat Univ Paris 1er Etage,1 Ave Claude Vellefaux Paris France F-75010
Citazione:
A. Parrado et al., "Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies", BR J HAEM, 104(4), 1999, pp. 738-741

Abstract

The retinoic acid receptor alpha (RAR alpha) protein plays a central role in myeloid differentiation, and chromosomal translocations disrupting the RAR alpha gene are implicated in the development of acute myeloid leukaemia (AML). To identify haemopoietic malignant disorders which may also be linked to RAR alpha abnormalities, Southern blot analysis was performed in DNA from 153 patients with haematological malignancies other than AML FAB type M3 using RAR alpha cDNA probes. Alterations of RAR alpha were detected in 1/42 myelodysplastic syndromes (MDS), 2/24 AML, 3/47 B-chronic lymphocytic leukaemias (B-CLL). 0/40 lymphomas and 0/60 normal individuals. These data strongly suggest that alterations of RAR alpha might predispose for myeloid and lymphoid disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:31:19