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Titolo:
Nucleus basalis injections of N-methyl-D-aspartate enhance memory of rats in the double Y-maze
Autore:
Mason, KI; Mallet, PE; Jhamandas, K; Boegman, RJ; Beninger, RJ;
Indirizzi:
Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 chol, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 hiat, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada QueensUniv Kingston ON Canada K7L 3N6 icol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 48, anno: 1999,
pagine: 65 - 71
SICI:
0361-9230(19990101)48:1<65:NBIONE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOREBRAIN CHOLINERGIC SYSTEM; ALZHEIMERS-DISEASE; WORKING-MEMORY; SUBSTANTIA INNOMINATA; EXCITOTOXIC LESIONS; COGNITIVE FUNCTIONS; GLOBUS PALLIDUS; PROJECTIONS; AMYGDALA; MAGNOCELLULARIS;
Keywords:
delayed alternation; FG 7142; double Y-maze; memory; NMDA; nucleus basalis magnocellularis; reference memory; working memory; glutamate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Beninger, RJ Queens Univ, Dept Psychol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 n, ON K7L 3N6, Canada
Citazione:
K.I. Mason et al., "Nucleus basalis injections of N-methyl-D-aspartate enhance memory of rats in the double Y-maze", BRAIN RES B, 48(1), 1999, pp. 65-71

Abstract

N-methyl-D-aspartate (NMDA) receptors have been implicated in learning andmemory. Many findings show that NMDA receptor antagonists impair memory. Few studies, however, have investigated the role of NMDA receptor agonists in mnemonic function. The present study examined the effects of nucleus basalis magnocellularis (nbm) injections of NMDA on memory. Rats were trained in a two-component double Y-maze task consisting of a spatial discriminationand a delayed alternation. Rats (n = 7) were surgically implanted with bilateral cannulae in the nbm prior to maze training. Once trained, animals received bilateral nbm injections (0.5 mu l) of saline (0.9%), NMDA (50, 75, and 100 ng/side), and the benzodiazepine receptor partial inverse agonist N-methyl-beta-carboline-3-carboxamide (FG 7142; 200 ng/side), in a counterbalanced order. During testing, delays (0, 30, 60 s) were introduced. Nbm FG 7142 or NMDA (50 ng/side) produced an improvement in the delayed alternation task. Results support the hypothesis that nbm NMDA receptors are involvedin cognitive processes mediating memory. (C) 1999 Elsevier Science Inc.

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Documento generato il 18/01/20 alle ore 13:11:24