Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain
Autore:
Nualart, F; Godoy, A; Reinicke, K;
Indirizzi:
ConcepcioneUniv, Fac Ciencias Biol, Dept Histol & Embriol, Concepcion, Chil Concepcion Univ Concepcion Chile ept Histol & Embriol, Concepcion, Chil
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 824, anno: 1999,
pagine: 97 - 104
SICI:
0006-8993(19990403)824:1<97:EOTHTG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BARRIER GLUCOSE-TRANSPORTER; RAT-BRAIN; GENE-EXPRESSION; INSITU HYBRIDIZATION; SMALL-INTESTINE; NERVOUS-SYSTEM; LOCALIZATION; SEQUENCE; PROTEIN; TISSUES;
Keywords:
hexose transporter; GLUT1; GLUT2; GLUT3; human fetal brain; blood-brain barrier; choroid plexus; brain capillary;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nualart, F Concepciononcepcion, Ciencias Biol, Dept Histol & Embriol, Casilla 160-C, C Concepcion Univ Casilla 160-C Concepcion Chile silla 160-C, C
Citazione:
F. Nualart et al., "Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain", BRAIN RES, 824(1), 1999, pp. 97-104

Abstract

We used immunohistochemistry with anti-glucose transporter antibodies to document the presence of facilitative hexose transporters in the fetal humanbrain. GLUT1 is expressed in all regions of the fetal brain from ages 10 to 21 weeks. GLUT1 was present in the endothelial cells of the brain capillaries, the epithelial cells of the choroid plexus and neurons. High expression of GLUT2 was observed in the granular layer of the cerebellum in brains 21 weeks old, but GLUT2 immunoreactivity was absent at earlier stages. GLUT3 and GLUT4 immunoreactivities were absent at all stages studied. GLUT5 immunoreactivity was evident only in the cerebellar region of 21-week old fetal brains. We conclude that GLUT1 plays a fundamental role in early human brain development. The data also suggest that the cerebellum of the developing brain has the capacity to transport fructose, a substrate that has not been previously identified as a source of metabolic energy in the adult humanbrain. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:09:33