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Titolo:
N-2-(azol-1(2)-yl)ethyliminodiacetic acids: A novel series of Gd(III) chelators as T-2 relaxation agents for magnetic resonance imaging
Autore:
Lopez, P; Seipelt, CG; Merkling, P; Sturz, L; Alvarez, J; Dolle, A; Zeidler, MD; Cerdan, S; Ballesteros, P;
Indirizzi:
UNED, Fac Ciencias, Dept Quim Organ & Biol, Madrid 28040, Spain UNED Madrid Spain 28040 ias, Dept Quim Organ & Biol, Madrid 28040, Spain Rhein Westfal TH Aachen, Inst Phys Chem, D-52056 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52056 , D-52056 Aachen, Germany CSIC, Inst Invest Biomed, E-28029 Madrid, Spain CSIC Madrid Spain E-28029 SIC, Inst Invest Biomed, E-28029 Madrid, Spain
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 3, volume: 7, anno: 1999,
pagine: 517 - 527
SICI:
0968-0896(199903)7:3<517:NAANSO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMINESCENCE PROPERTIES; CONTRAST AGENTS; COMPLEXES; EUROPIUM(III); HETEROCYCLES; LIGANDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ballesteros, P UNED,ainc Ciencias, Dept Quim Organ & Biol, Senda Rey S-N, Madrid 28040, Sp UNED Senda Rey S-N Madrid Spain 28040 -N, Madrid 28040, Sp
Citazione:
P. Lopez et al., "N-2-(azol-1(2)-yl)ethyliminodiacetic acids: A novel series of Gd(III) chelators as T-2 relaxation agents for magnetic resonance imaging", BIO MED CH, 7(3), 1999, pp. 517-527

Abstract

The synthesis, physicochemical properties, and toxicological implications of a novel series of N-2-(azol-1(2)-yl)ethyliminodiacetic acids, useful as contrast agents for magnetic resonance imaging are reported. Compounds wereprepared by alkylation of methyl iminodiacetate with N-2-bromoethylazoles and subsequent hydrolysis. Stability constants of the corresponding Gd(III)complexes and T-1 and T-2 relaxivities were determined and interpreted in terms of optimized geometries obtained by semiempirical PM3 calculations. Compounds show increased T-2 relaxivity and decreased toxicity in vitro as compared to EDTA-Gd(III) complexes. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:05:15