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Titolo:
Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans:A comparison of two time points
Autore:
Javanmard, M; Shlik, J; Kennedy, SH; Vaccarino, FJ; Houle, S; Bradwejn, J;
Indirizzi:
Univat,tawa, Stress & Anxiety Clin Res Unit, Royal Ottawa Hosp, Dept Psychi Univ Ottawa Ottawa ON Canada K1Z 7K4 Unit, Royal Ottawa Hosp, Dept Psychi Univ,Toronto, Psychobiol & Clin Trials Res Unit Anxiety, Mood & Anxiety Div Univ Toronto Toronto ON Canada ials Res Unit Anxiety, Mood & Anxiety Div Univ Toronto, Clarke Inst Psychiat, PET Ctr, Toronto, ON, Canada Univ Toronto Toronto ON Canada st Psychiat, PET Ctr, Toronto, ON, Canada Tartu State Univ, EE-202400 Tartu, Estonia Tartu State Univ Tartu Estonia EE-202400 Univ, EE-202400 Tartu, Estonia
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 45, anno: 1999,
pagine: 872 - 882
SICI:
0006-3223(19990401)45:7<872:NCOCPA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; ANTERIOR CINGULATE CORTEX; CEREBRAL BLOOD-FLOW; POSTTRAUMATIC-STRESS-DISORDER; CHOLECYSTOKININ-TETRAPEPTIDE; PET IMAGES; FUNCTIONAL NEUROANATOMY; SYMPTOM PROVOCATION; HUMAN-BRAIN; ANXIETY;
Keywords:
positron emission tomography; panic attacks; cholecystokinin-4; anticipatory anxiety; cerebral blood flow; healthy volunteers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Bradwejn, J Univat,tawa, Stress & Anxiety Clin Res Unit, Royal Ottawa Hosp, Dept Psychi Univ Ottawa 1145 Carling Ave,Carmichael Bldg,Room 2005 OttawaON Canada K1Z 7K4
Citazione:
M. Javanmard et al., "Neuroanatomic correlates of CCK-4-induced panic attacks in healthy humans:A comparison of two time points", BIOL PSYCHI, 45(7), 1999, pp. 872-882

Abstract

Background: Several functional imaging studies have demonstrated increasesof brain activity in the temporofrontal, cingulate, and claustrum regions during a pharmacologically induced panic attack when scanning was done at asingle point in time. However, no study has evaluated changes in brain activity at two time points during a panic attack. We hypothesized that in response to a single bolus injection of the panicogen cholecystokinin-4 (CCK-4) in healthy volunteers, changes in regional cerebral blood flow (rCBF) might be different if scanning were done at two different time points. Methods: To test this hypothesis, we conducted a single-blind study, usingpositron emission tomography (PET). To determine the time effect of panic attack on brain activity, we performed either early scan or late scan covering the first or the second minute after CCK-4 bolus injection, respectively. The PET images were analyzed by statistical parametric mapping (SPM) followed by region of interest (ROI) analysis. Results: The results showed significant differences between the early and the late scan. The early effects of CCK-4 are accompanied by increases in rCBF in the hypothalamic region, whereas the late scan showed an increase inrCBF in the claustrum-insular region. Reductions in rCBF were observed forboth time groups in the medial frontal regions. A separate scan for anticipatory anxiety demonstrated rCBF increases in the anterior cingulate regionand decreases in the occipital regions. Conclusions: These results may support the hypothesis that changes in rCBFas a function of time during CCK-4-induced panic might correspond to a neurocircuitry involved in panic attacks. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 11:20:48