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Titolo:
Low platelet-poor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder
Autore:
Spivak, B; Vered, Y; Graff, E; Blum, I; Mester, R; Weizman, A;
Indirizzi:
Ness Ziona Mental Hlth Ctr, Res Unit, IL-74100 Ness Ziona, Israel Ness Ziona Mental Hlth Ctr Ness Ziona Israel IL-74100 Ness Ziona, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Sourasky Med Ctr, Lab Clin Biochem, Tel Aviv, Israel Sourasky Med Ctr TelAviv Israel tr, Lab Clin Biochem, Tel Aviv, Israel Rabin Med Ctr, Dept Endocrinol, Petah Tiqwa, Israel Rabin Med Ctr Petah Tiqwa Israel , Dept Endocrinol, Petah Tiqwa, Israel Felsenstein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel Felsenstein Med Res Ctr Petah Tiqwa Israel sychiat, Petah Tiqwa, Israel Rabin Med Ctr, Geha Psychiat Hosp, Res Unit, IL-49100 Petah Tiqwa, Israel Rabin Med Ctr Petah Tiqwa Israel IL-49100 , IL-49100 Petah Tiqwa, Israel
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 45, anno: 1999,
pagine: 840 - 845
SICI:
0006-3223(19990401)45:7<840:LPPCOS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATECHOLAMINE EXCRETION; PHENELZINE TREATMENT; VETERANS; ACTIVATION; PTSD; NOREPINEPHRINE; MICRODIALYSIS; PERSPECTIVE; FLUOXETINE; RESPONSES;
Keywords:
posttraumatic stress disorder; serotonin; catecholamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Spivak, B Ness Ziona Mental Hlth Ctr, Res Unit, POB 1, IL-74100 Ness Ziona, Israel Ness Ziona Mental Hlth Ctr POB 1 Ness Ziona Israel IL-74100 ael
Citazione:
B. Spivak et al., "Low platelet-poor plasma concentrations of serotonin in patients with combat-related posttraumatic stress disorder", BIOL PSYCHI, 45(7), 1999, pp. 840-845

Abstract

Background: Combat-related posttraumatic stress disorder (CR-PTSD) is associated with a dysregulation of various neurotransmitter systems. Methods: We assessed levels of platelet-poor plasma (PPP) norepinephrine (NE), and serotonin (5-HT), and 24-hour urinary excretion of NE, dopamine (DA), and homovanillic acid (HVA) in 17 male outpatients with untreated chronic CR-PTSD (age, 33.1 +/- 7.4 years) and 10 normal control subjects (age, 35.8 +/- 2.7 years). Results: Compared with the control subjects, the PTSD patients showed significantly lower PPP 5-HT levels, elevated PPP NE levels, and significantly higher mean 24-hour urinary excretion of all three catecholamines (NE, DA,and HVA). The 24-hour urinary HVA values of the CR-PTSD patients correlated significantly and positively with the total Impact of Event Scale scores and the avoidance symptoms cluster scores, and the PPP 5-HT levels correlatednegatively with the Hamilton Anxiety Rating Scale scores. The PPP NE/5-HT ratio was significantly higher in the study group than in the control subjects. Conclusions: We believe this combined enhanced noradrenergic activity and diminished 5-HT activity may be relevant to the neurobiology of CR-PTSD. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 06/06/20 alle ore 01:34:35