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Titolo:
Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study
Autore:
Bremner, JD; Staib, LH; Kaloupek, D; Southwick, SM; Soufer, R; Charney, DS;
Indirizzi:
Yale Univ, Inst Psychiat, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Dept Diagnost Radiol, Sch Med, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Radiol, Sch Med, New Haven, CT 06520 USA Natl Ctr Posttraumat Stress Disorder, New Haven, CT USA Natl Ctr Posttraumat Stress Disorder New Haven CT USA New Haven, CT USA Yale VA PET Ctr, New Haven, CT USA Yale VA PET Ctr New Haven CT USAYale VA PET Ctr, New Haven, CT USA VA Connecticut Healthcare Ctr, New Haven, CT USA VA Connecticut HealthcareCtr New Haven CT USA re Ctr, New Haven, CT USA VA Med Ctr, Boston, MA USA VA Med Ctr Boston MA USAVA Med Ctr, Boston, MA USA Boston Univ, Dept Psychiat, Boston, MA USA Boston Univ Boston MA USABoston Univ, Dept Psychiat, Boston, MA USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 45, anno: 1999,
pagine: 806 - 816
SICI:
0006-3223(19990401)45:7<806:NCOETT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; FUNCTIONAL NEUROANATOMY; HIPPOCAMPAL VOLUME; PANIC DISORDER; NORADRENERGIC MECHANISMS; SYMPTOM PROVOCATION; LOCUS COERULEUS; SEXUAL ABUSE; ANXIETY;
Keywords:
positron emission tomography; memory; posttraumatic stress disorder; frontal cortex; cingulate; function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, JD YaleHaven, Inst Psychiat, Sch Med, Dept Psychiat, POB 208038,Yale Stn, New Yale Univ POB 208038,Yale Stn New Haven CT USA 06520 Stn, New
Citazione:
J.D. Bremner et al., "Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study", BIOL PSYCHI, 45(7), 1999, pp. 806-816

Abstract

Background: Patients with posttraumatic stress disorder (PTSD) show a reliable increase in PTSD symptoms and physiological reactivity following exposure to traumatic pictures and sounds. In this study neural correlates of exposure to traumatic pictures and sounds were measured in PTSD. Methods: Positron emission tomography and H<SUP>2</SUP>[<SUP>15</SUP>O]<SUP></SUP> were used to measure cerebral blood flow during exposure to combat-related and neutral pictures and sounds in Vietnam combat veterans with and without PTSD. Results: Exposure to traumatic material in PTSD (but not non-PTSD) subjects resulted in a decrease in blood flow in medial prefrontal cortex (area 25), an area postulated to play a role in emotion through inhibition of amygdala responsiveness. Non-PTSD subjects activated anterior cingulate (area 24) to a greater degree than PTSD patients. There were also differences in cerebral blood flow response in areas involved in memory and visuospatial processing (and by extension response to threat), including posterior cingulate (area 23), precentral (motor) and inferior parietal cortex, and lingual gyrus. There was a pattern of increases in PTSD and decreases in non-PTSD subjects in these areas. Conclusions: The findings suggest that functional alterations in specific cortical and subcortical brain areas involved in memory, visuospatial processing, and emotion underlie the symptoms of patients with PTSD. (C) 1999 Society of Biological Psychiatry.

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Documento generato il 25/02/20 alle ore 08:09:58