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Titolo:
Concanavalin A binding to oligosaccharide chain leads to alterations in properties of Band 3
Autore:
Zhang, ZG; Lu, JZ; Chen, JW;
Indirizzi:
AcadChinaca, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples RAcad Sinica Beijing Peoples R China 100101 ol, Beijing 100101, Peoples R
Titolo Testata:
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL
fascicolo: 3, volume: 47, anno: 1999,
pagine: 377 - 385
SICI:
1039-9712(199903)47:3<377:CABTOC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-ERYTHROCYTE-MEMBRANE; DIFFERENTIAL SCANNING CALORIMETRY; GLUCOSE-TRANSPORT ACTIVITY; ANION TRANSPORT; C-TRANSITION; PROTEIN; CELL; AGGLUTINABILITY; GLYCOSYLATION; SKELETON;
Keywords:
Concanavalin A; Band 3; DSC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, JW AcadRSinica, Inst Biophys, 15 Datun,Chaoyang Dist, Beijing 100101, Peoples Acad Sinica 15 Datun,Chaoyang Dist Beijing Peoples R China 100101
Citazione:
Z.G. Zhang et al., "Concanavalin A binding to oligosaccharide chain leads to alterations in properties of Band 3", BIOC MOL B, 47(3), 1999, pp. 377-385

Abstract

Anion transport activity and thermotropic behavior of Band 3 are found to be altered after binding of concanavalin (Con A) to human erythrocyte ghosts and isolated Band 3. At lower Con A concentration, the rate coefficients of anion transport enhance with increasing Con A concentration, while noticeable changes of the largest calorimetric endotherm of human erythrocyte membranes termed the C transition (Band 3) can not be observed. With 50 mu g/ml of Con A, the rate coefficient of Con A-modified ghosts increases 34.4% in comparison with that of normal ghosts. Binding of Con A in lower concentration to ghosts bring about increase of fluidity of lipid which maybe contribute to increase anion transport via Band 3. At higher Con A concentration, the C transition tend to lower temperature with increase in Con A concentration. the C transition is shifted from 69.25 degrees C to 66.25 degrees C with 2.5mg/ml Con A. It is suggested that the Con A-modified Band 3 possess a looser structure than normal one.

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Documento generato il 14/07/20 alle ore 11:28:36