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Titolo:
Assessment of bone mineral, density in adults with a history of juvenile chronic arthritis - A cross-sectional long-term followup study
Autore:
Zak, M; Hassager, C; Lovell, DJ; Nielsen, S; Henderson, CJ; Pedersen, FK;
Indirizzi:
Rigshosp, Univ Clin Pediat 2, Dept 4064, DK-2100 Copenhagen O, Denmark Rigshosp Copenhagen Denmark O , Dept 4064, DK-2100 Copenhagen O, Denmark Danish Res Fdn, Ballerup, Denmark Danish Res Fdn Ballerup DenmarkDanish Res Fdn, Ballerup, Denmark Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA Childrens Hosp Cincinnati OH USA 45229 Med Ctr, Cincinnati, OH 45229 USA
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 4, volume: 42, anno: 1999,
pagine: 790 - 798
SICI:
0004-3591(199904)42:4<790:AOBMDI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHEUMATOID-ARTHRITIS; SERUM OSTEOCALCIN; CHILDREN; METABOLISM; OSTEOPOROSIS; OSTEOPENIA; THERAPY; GLUCOCORTICOIDS; ABSORPTIOMETRY; STEROIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Zak, M Rigshosp,O,niv Clin Pediat 2, Dept 4064, Blegdamsvej 9, DK-2100 Copenhagen Rigshosp Blegdamsvej 9 Copenhagen Denmark O 9, DK-2100 Copenhagen
Citazione:
M. Zak et al., "Assessment of bone mineral, density in adults with a history of juvenile chronic arthritis - A cross-sectional long-term followup study", ARTH RHEUM, 42(4), 1999, pp. 790-798

Abstract

Objective. To assess bone mineral density (BMD) and bone turnover in adults with a history of juvenile chronic arthritis (JCA) or persistent JCA, andto identify predictors of reduced BMD. Methods. Sixty-five white patients (mean age 32.2 years) with a history ofJCA and 65 age-, sex-, height-, and weight-matched healthy control subjects participated in the study. Densitometry of the left hip and the lumbar spine was performed, and osteocalcin (bone formation marker) and crosslinks (bone resorption marker) were measured. In addition, bone-related clinical parameters were assessed in the JCA group. Results. BMD in the hip and lumbar spine was significantly lower in the JCA group than in the controls. Levels of osteocalcin and crosslinks were significantly increased in the JCA group. According to WHO definitions, significantly more subjects in the JCA group had "osteopenia" and "osteoporosis" than would be expected in a normal population sample. Active disease at thetime of the study (1996-1997), baseline erosions evaluated in 1979, Steinbrocker functional class in 1996-1997, polyarticular course of JCA, and history of systemic steroid treatment for more than 1 year were significantly associated with reduced BMD. In linear regression analysis including both the JCA and control groups, presence of JCA proved to be the factor most strongly associated with reduced BMD, explaining similar to 20% of its variation. Conclusion. Reduced BMD and evidence of increased bone turnover suggest that JCA patients may be at risk of developing premature osteoporosis and associated fractures later in life. The data are consistent with the concept that BMD in JCA is determined by many factors.

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Documento generato il 16/07/20 alle ore 06:17:53