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Titolo:
A complete remote-control system for reliable preparation of [F-18]altanserin
Autore:
Tan, PZ; Baldwin, RM; Soufer, R; Garg, PK; Charney, DS; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, VA PET Ctr, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 sychiat, VA PET Ctr, W Haven, CT 06516 USA
Titolo Testata:
APPLIED RADIATION AND ISOTOPES
fascicolo: 5, volume: 50, anno: 1999,
pagine: 923 - 927
SICI:
0969-8043(199905)50:5<923:ACRSFR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; F-18 ALTANSERIN; RADIOLIGAND; RECEPTORS; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Tan, PZ Yale Univ, Sch Med, Dept Psychiat, VA PET Ctr, 116A2, W Haven, CT 06516 USA Yale Univ 116A2 W Haven CT USA 06516 116A2, W Haven, CT 06516 USA
Citazione:
P.Z. Tan et al., "A complete remote-control system for reliable preparation of [F-18]altanserin", APPL RAD IS, 50(5), 1999, pp. 923-927

Abstract

A complete remote control system was constructed for production of the PET5-HT2A ligand [F-18]altanserin by nitro-for-fluoro exchange. Comparing with published methods, the key features include (1) conducting azeotropic distillation and nucleophilic displacement in an open vessel heated by a commercial microwave oven; (2) purifying the product by a single HPLC procedure and (3) removing HPLC solvent by solid phase extraction. The preparation took 114 min with 23% yield and high quality. (C) 1999 Elsevier Science Ltd. All rights reserved.

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Documento generato il 18/01/20 alle ore 13:03:30