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Titolo:
Novel artificial endonucleases inhibit base excision repair and potentiatethe cytotoxicity of DNA-damaging agents on L1210 cells
Autore:
Barret, JM; Etievant, C; Fahy, J; Lhomme, J; Hill, BT;
Indirizzi:
Ctr Rech Pierre Fabre, Div Cancerol Expt, F-81106 Castres, France Ctr RechPierre Fabre Castres France F-81106 pt, F-81106 Castres, France Ctr Rech Pierre Fabre, Div Chim Med 5, F-81106 Castres, France Ctr Rech Pierre Fabre Castres France F-81106 5, F-81106 Castres, France Univ Grenoble 1, CNRS, UMR 5616, LEDSS, F-38041 Grenoble, France Univ Grenoble 1 Grenoble France F-38041 LEDSS, F-38041 Grenoble, France
Titolo Testata:
ANTI-CANCER DRUGS
fascicolo: 1, volume: 10, anno: 1999,
pagine: 55 - 65
SICI:
0959-4973(199901)10:1<55:NAEIBE>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAMSTER OVARY CELLS; POLYMERASE-BETA; APURINIC SITES; ABASIC SITES; RESISTANCE; GLYCOSYLASE; OVEREXPRESSION; ALKYLATION; EFFICIENT; INDUCTION;
Keywords:
abasic site; alkylating agents; artificial endonucleases; excision repair; potentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Barret, JM Ctres,ch Pierre Fabre, Div Cancerol Expt, 17 Ave Jean Moulin, F-81106 Castr Ctr Rech Pierre Fabre 17 Ave Jean Moulin Castres France F-81106
Citazione:
J.M. Barret et al., "Novel artificial endonucleases inhibit base excision repair and potentiatethe cytotoxicity of DNA-damaging agents on L1210 cells", ANTI-CANC D, 10(1), 1999, pp. 55-65

Abstract

A series of molecules with apurinic/apyrimidic (AP) endonuclease activity targeted to abasic sites in DNA, which incorporate an intercalating moiety linked to a purine base by a polyamino chain and recognize and cleave abasic sites in DNA with high efficiency, has been studied. The aim was first toestablish whether these compounds were inhibitors of base excision DNA repair, since abasic sites are generated during this process. Using an extension of a recently established methodology, two members of this series have been identified as definite repair inhibitors. Secondly, the potential of using such compounds as sensitizers of alkylating agents has been investigated by determining the cytotoxic activity of these compounds on L1210 cells in culture. A concentration-dependent potentiation of nitrosoureas has been demonstrated, but interpretation is complicated by the inherent cytotoxic properties of the test compounds themselves. Such molecules, however, provide interesting lead compounds for new strategies aimed at enhancing the cytotoxic potential of clinically useful DNA-damaging agents. [(C) 1999 Lippincott Williams & Wilkins.]

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:38:19