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Titolo:
Effect of major hepatectomy on glucose and lactate metabolism
Autore:
Chiolero, R; Tappy, L; Gillet, M; Revelly, JP; Roth, H; Cayeux, C; Schneiter, P; Leverve, X;
Indirizzi:
CHUzerlands, Surg Intens Care Unit, Dept Anesthesia, CH-1011 Lausanne, Swit CHU Vaudois Lausanne Switzerland CH-1011 sthesia, CH-1011 Lausanne, Swit CHU Vaudois, Dept Physiol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland CHU Vaudois, Dept Surg, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland Univ Lausanne, Fac Med, CH-1015 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1015 CH-1015 Lausanne, Switzerland Univ Grenoble, Fac Med, Grenoble, France Univ Grenoble Grenoble FranceUniv Grenoble, Fac Med, Grenoble, France
Titolo Testata:
ANNALS OF SURGERY
fascicolo: 4, volume: 229, anno: 1999,
pagine: 505 - 513
SICI:
0003-4932(199904)229:4<505:EOMHOG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONINVASIVE ASSESSMENT; GLYCOGEN KINETICS; SODIUM LACTATE; HUMANS; GLUCONEOGENESIS; LIVER; HOMEOSTASIS; NUTRITION; CIRRHOSIS; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chiolero, R CHU Vaudois, Dept Anesthesiol & Surg ICU, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 usanne, Switzerland
Citazione:
R. Chiolero et al., "Effect of major hepatectomy on glucose and lactate metabolism", ANN SURG, 229(4), 1999, pp. 505-513

Abstract

Background The liver plays an important role in glucose and lactate metabolism. Major hepatectomy may therefore be suspected to cause alterations of glucose and lactate homeostasis. Methods Thirteen subjects were studied: six patients after major hepatectomy and seven healthy subjects who had fasted overnight. Glucose turnover was measured with 6,6(2)H glucose. Lactate metabolism was assessed using two complementary approaches: C-13-glucose synthesis and (13)CO2 production from an exogenous C-13-labeled lactate load infused over 15 minutes were measured, then the plasma lactate concentrations observed over 185 minutes afterlactate load were fitted using a biexponential model to calculate lactate clearance, endogenous production, and half-lives. Results Three to five liver segments were excised. Compared to healthy controls, the following results were observed in the patients: 1) normal endogenous glucose production; 2) unchanged C-13-lactate oxidation and transformation into glucose; 3) similar basal plasma lactate concentration, lactate clearance, and lactate endogenous production; 4) decreased plasma lactate half-life 1 and increased half-life 2. Conclusions Glucose and lactate metabolism are well maintained in patientsafter major hepatectomy, demonstrating a large liver functional reserve. Reduction in the size of normal liver parenchyma does not lead to hyperlactatemia. The use of a pharmacokinetic model, however, allows the detection ofsubtle alterations of lactate metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:57:40