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Titolo:
Recommendations for medical management of hereditary breast and ovarian cancer: the INSERM-FNCLCC ad hoc committee
Autore:
Eisinger, F; Alby, N; Bremond, A; Dauplat, J; Espie, M; Janiaud, P; Kuttenn, F; Lebrun, JP; Lefranc, JP; Pierret, J; Sobol, H; Stoppa-Lyonnet, D; Thouvenin, D; Tristant, H; Feingold, J;
Indirizzi:
Inst J Paoli I Calmettes, F-13009 Marseille, France Inst J Paoli I Calmettes Marseille France F-13009 3009 Marseille, France
Titolo Testata:
ANNALES DE GENETIQUE
fascicolo: 1, volume: 42, anno: 1999,
pagine: 51 - 64
SICI:
0003-3995(1999)42:1<51:RFMMOH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
FRE
Soggetto:
SUSCEPTIBILITY GENE; BRCA1 MUTATIONS; FAMILY HISTORY; FOLLOW-UP; WOMEN; RISK; LINE; INFORMATION; MAMMOGRAPHY; GUIDELINES;
Keywords:
BRCA1; BRCA2; breast cancer; guidelines; ovarian cancer; preventive care;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Eisinger, F Inst J Paoli I Calmettes, 232 Bd St Marguerite, F-13009 Marseille, France Inst J Paoli I Calmettes 232 Bd St Marguerite Marseille FranceF-13009
Citazione:
F. Eisinger et al., "Recommendations for medical management of hereditary breast and ovarian cancer: the INSERM-FNCLCC ad hoc committee", ANN GENET, 42(1), 1999, pp. 51-64

Abstract

Background: Almost 10% of breast and ovarian cancer are inherited, and themajority are linked to BRCA1 and BRCA2 germline mutations. Despite the uncertainty in the management of women gene carriers, consensus guidelines were defined to assist practitioners', and patients' decisions about the health care decisions to be made. Methodology: The Ad Hoc Committee consisted of14 experts designated by the French National Institute for Health and Medical Research. They all attended eleven workshops at which a systematic analytical review of more than 3500 articles was carried out. Five additional experts critically analysed the first version of the report. Criteria and Descision Process: Two thresholds were defined on a probability scale giving the risk of developing breast or ovarian cancer, to serve as a means of deciding as whether an intervention is worthwhile. The first threshold is thatabove which an intervention call be envisaged or recommended; the second is that under which an intervention can be ruled out; between the two, the decision has to be made on a each by case basis. Strategies Analyzed: About breast cancer: 1) hormonal interventions; 2) primary prevention (diet, family planning and chemoprevention); 3) screening (breast self-examination, clinician breast examination, tumor markers, imaging); 4) prophylactic mastectomy. About ovarian cancer: I)hormonal stimulation; 2) screening (clinical screening, ultrasound and tumor markers); 3) prophylactic oophorectomy. Main conclusions: With each strategy the following points were dealt with : the information to be delivered to the consultand, the procedure and the indications. In addition, the Committee's opinion about BRCA1 and BRCA2 mutation screening is that population-based or even large scale implementation art: not justified. Although no scientific evidence is available, the Committee feels that specific management is indispensable and advocates the use of defined and evaluated procedures, and involvement in clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 00:15:54