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Titolo:
Halothane induces calcium release from human skinned masseter muscle fibers
Autore:
Reyford, H; Adnet, PJ; Tavernier, B; Beague, S; Ferri, J; Krivosic-Horber, RM; Haudecoeur, G;
Indirizzi:
CHU Lille, Hop R Salengro, Serv Accueil & Urgence, F-59037 Lille, France CHU Lille Lille France F-59037 Accueil & Urgence, F-59037 Lille, France
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 4, volume: 90, anno: 1999,
pagine: 1019 - 1025
SICI:
0003-3022(199904)90:4<1019:HICRFH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; INDUCED CA RELEASE; MALIGNANT HYPERTHERMIA; SARCOPLASMIC-RETICULUM; SUCCINYLCHOLINE; SPASM; CAFFEINE; RIGIDITY; ANESTHETICS; SENSITIVITY;
Keywords:
masseter muscle rigidity; skinned fibers; volatile anesthetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Adnet, PJ CHU Lille, Hop R Salengro, Serv Accueil & Urgence, F-59037 Lille, France CHU Lille Lille France F-59037 Urgence, F-59037 Lille, France
Citazione:
H. Reyford et al., "Halothane induces calcium release from human skinned masseter muscle fibers", ANESTHESIOL, 90(4), 1999, pp. 1019-1025

Abstract

Background: An increase in masseter muscle tone in response to halothane or succinylcholine anesthesia (or both) can be observed in healthy persons. Thus the authors compared the fiber-type halothane and succinylcholine sensitivities in human masseter and vastus lateralis muscles. Methods: Masseter and vastus lateralis muscle segments were obtained from 13 and 9 healthy persons, respectively, After chemical skinning of a singlefiber and loading the sarcoplasmic reticulum with Ca++ 0.16 mu M solution,halothane (0.5-4 vol% bubbled in the incubating solution), succinylcholine(0.1 mu M to 10 nM), or both sensitivities were defined as the concentration inducing more than 10% of the maximum tension obtained by application of16 mu M Ca++ solution. The myofilament response to Ca++ was studied with and without halothane by observing the isometric tension of skinned masseterfibers challenged with increasing concentrations of Ca++, Muscle fiber type was determined by the difference in strontium-induced tension measurements. Results: A significant difference in halothane sensitivity was found between type 1 masseter fibers (0.6 +/- 0.2 vol%; mean +/- SD) versus type 1 (2.7 +/- 0.6 vol%) and type 2 vastus lateralis muscle (2.5 +/- 0.4 vol%), Succinylcholine did not induce Ca++ release by the sarcoplasmic reticulum. in the masseter muscle, 0.75 vol% halothane decreased the maximal activated tension by 40% but did not change the Ca++ concentration that yields 50% of the maximal tension. Conclusions: The very low halothane threshold for Ca++ release from the masseter muscle usually could be counteracted by a direct negative inotropic effect on contractile proteins. However, halothane may increase the sensitivity of the sarcoplasmic reticulum Ca++ release to succinylcholine-induced depolarization, leading to an increase in masseter muscle tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:28:56