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Titolo:
Use of contrast-enhanced computed tomography to measure clearance per unitrenal volume: A novel measurement of renal function and fractional vascular volume
Autore:
Tsushima, Y; Blomley, MJK; Kusano, S; Endo, K;
Indirizzi:
Natl Def Med Coll, Dept Radiol, Tokorozawa, Saitama, Japan Natl Def Med Coll Tokorozawa Saitama Japan l, Tokorozawa, Saitama, Japan Hammersmith Hosp, Dept Imaging, London, England Hammersmith Hosp London England ith Hosp, Dept Imaging, London, England Gunma Univ Hosp, Dept Diagnost Radiol & Nucl Med, Gunma, Japan Gunma Univ Hosp Gunma Japan pt Diagnost Radiol & Nucl Med, Gunma, Japan
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 4, volume: 33, anno: 1999,
pagine: 754 - 760
SICI:
0272-6386(199904)33:4<754:UOCCTT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; IOHEXOL CLEARANCE; HUMAN KIDNEY; PERFUSION; REPRODUCIBILITY; CREATININE; AGE;
Keywords:
kidney; clearance; perfusion; dynamic computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Tsushima, Y Motojima Gen Hosp, Dept Radiol, 3-8 Nishi Honcho, Gunma 3730033, Japan Motojima Gen Hosp 3-8 Nishi Honcho Gunma Japan 3730033 Japan
Citazione:
Y. Tsushima et al., "Use of contrast-enhanced computed tomography to measure clearance per unitrenal volume: A novel measurement of renal function and fractional vascular volume", AM J KIDNEY, 33(4), 1999, pp. 754-760

Abstract

The iodinated contrast agents used for computed tomography (CT) have pharmacokinetics similar to inulin and can measure physiological indices, such as clearance per unit renal volume (alpha/V) and fractional vascular volume (fvv), Clinical experience with these techniques is, however, scanty, and the present study explored their potential in subjects with and without renal dysfunction. In a series of subjects, a single slice of kidney was scanned sequentially after the bolus injection of contrast material. Time-attenuation curves were constructed, and alpha/V and fvv were calculated using a Patlak graphic analysis, In the first part of the study, 50 normal kidneys in 35 subjects (aged 21 to 75 years) were studied. In the second stage, alpha/N was compared with glomerular filtration rate (GFR) measurements in 24 patients with diabetes (aged 28 to 84 years) with or without renal dysfunction. In normal kidneys, alpha/V averaged 0.49 +/- 0.11 mL/min/mL and fvv averaged 35% +/- 12%, These values agree with literature data obtained using other techniques. A negative correlation was seen between age and alpha/V (r= 0.66; P < 0.0001), but not fvv. In patients with diabetes, a strong correlation was observed between renal clearance values, calculated from CT andcorrected for renal volume, and GFR (r = 0.87; P < 0.0001). Dynamic CT canprovide quantitative renal physiological information on a regional basis noninvasively, (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:36:44