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Titolo:
The concept of target features in schizophrenia research
Autore:
Tsuang, MT; Faraone, SV;
Indirizzi:
Harvard,Univ, Massachusetts Mental Hlth Ctr, Sch Med, Dept Psychiat, Boston Harvard Univ Boston MA USA 02115 Hlth Ctr, Sch Med, Dept Psychiat, Boston Brockton W Roxbury Vet Affairs Med Ctr, Boston, MA USA Brockton W Roxbury Vet Affairs Med Ctr Boston MA USA Ctr, Boston, MA USA Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 th, Dept Epidemiol, Boston, MA 02115 USA Harvard Inst psychiat Epidemiol & Genet, Boston, MA USA Harvard Inst psychiat Epidemiol & Genet Boston MA USA et, Boston, MA USA Massachusetts Gen Hosp, Psychiat Serv, Pediat Psychopharmacol Unit, Boston, Massachusetts Gen Hosp Boston MA USA ediat Psychopharmacol Unit, Boston,
Titolo Testata:
ACTA PSYCHIATRICA SCANDINAVICA
, volume: 99, anno: 1999, supplemento:, 395
pagine: 2 - 11
SICI:
0001-690X(1999)99:<2:TCOTFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
JERUSALEM INFANT-DEVELOPMENT; HIGH-RISK-PROJECT; SUSCEPTIBILITY LOCUS; LINKAGE ANALYSIS; PERCEPTUAL ABERRATION; CHROMOSOME 6P24-22; PSYCHOTIC-PATIENTS; EXPRESSED EMOTION; TWINS DISCORDANT; COMPLEX DISEASES;
Keywords:
schizophrenia; genetics; psychopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Tsuang, MT Harvardwoodv, Massachusetts Mental Hlth Ctr, Sch Med, Dept Psychiat, 74 Fen Harvard Univ 74 Fenwood Rd Boston MA USA 02115 Psychiat, 74 Fen
Citazione:
M.T. Tsuang e S.V. Faraone, "The concept of target features in schizophrenia research", ACT PSYC SC, 99, 1999, pp. 2-11

Abstract

Target features are clinical or neurobiological characteristics that are expressions of the underlying predisposition to an illness. They comprise a wide range of phenomena, from the classic signs and symptoms of psychopathology to sophisticated measures of brain structure and function. For schizophrenia, many target features have been identified. These include eye tracking dysfunction, attentional impairment, allusive thinking, neurological signs, thought disorder, characteristic auditory evoked potentials, neuropsychological impairment, structural brain abnormalities and functional brain abnormalities. In their most pathological forms, these features are present among many schizophrenic patients. yet it is their presence among their non-psychotic relatives that shows them to be target features. We discuss the theoretical background for target features, present examples and describe how the discovery of target features has implications for schizophrenia research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:09:14