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Titolo:
Catecholamines in pericardial fluid of normotensive, spontaneously hypertensive and reserpine-treated rats
Autore:
Klemola, R; Huttunen, P; Laine, M; Weckstrom, M; Hirvonen, J;
Indirizzi:
Oulu Univ, Dept Physiol, Oulu 90220, Finland Oulu Univ Oulu Finland 90220 ulu Univ, Dept Physiol, Oulu 90220, Finland Oulu Univ, Dept Forens Med, Oulu 90220, Finland Oulu Univ Oulu Finland 90220 Univ, Dept Forens Med, Oulu 90220, Finland Oulu Univ, Dept Phys Sci, Div Biophys, Oulu 90220, Finland Oulu Univ Oulu Finland 90220 Phys Sci, Div Biophys, Oulu 90220, Finland Oulu Univ, Bioctr Oulu, Oulu 90220, Finland Oulu Univ Oulu Finland 90220Oulu Univ, Bioctr Oulu, Oulu 90220, Finland
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 3, volume: 165, anno: 1999,
pagine: 293 - 297
SICI:
0001-6772(199903)165:3<293:CIPFON>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; CARDIAC-HYPERTROPHY; EXERCISE; RELEASE;
Keywords:
heart; hypertensive rat; noradrenaline; pericardial fluid; reserpine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Weckstrom, M Oulu Univ, Dept Physiol, Kajaanintie 52A, Oulu 90220, FinlandOulu Univ Kajaanintie 52A Oulu Finland 90220 90220, Finland
Citazione:
R. Klemola et al., "Catecholamines in pericardial fluid of normotensive, spontaneously hypertensive and reserpine-treated rats", ACT PHYSL S, 165(3), 1999, pp. 293-297

Abstract

In this study our aims were to investigate the presence and source of catecholamines in pericardial fluid of normotensive, reserpine-treated and spontaneously hypertensive rats. We found that noradrenaline is the only detectable catecholamine present in rat pericardial fluid. The effect of reserpine 6, 12, and 24 h after pre-treatment with 5 mg kg(-1) (8.2 mu mol kg(-1)) i.p, shows that the concentration of noradrenaline in pericardial fluid reflects the amount of noradrenaline released within the heart rather than theamount of noradrenaline in plasma. Using spontaneously hypertensive rats (SHR) as a model for primary hypertension we could show that the level of pericardial noradrenaline is approximately threefold in the pericardial fluidof the SHRs when compared to respective values of age-matched normotensiveWistar-Kyoto rats (WKY), suggesting that there was an increased noradrenaline overflow in the hearts of the SHRs. in conclusion, determination of thenoradrenaline concentration in the pericardial fluid might provide a new method for estimating the release of noradrenaline in the heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:13:35