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Titolo:
REDUCED KYNURENINE AMINOTRANSFERASE-I ACTIVITY IN SHR RATS MAY BE DUETO LACK OF KAT-IB ACTIVITY
Autore:
KAPOOR V; THURUTHYIL SJ; HUMAN B;
Indirizzi:
UNIV NEW S WALES,FAC MED,SCH PHYSIOL & PHARMACOL SYDNEY NSW 2052 AUSTRALIA
Titolo Testata:
NeuroReport
fascicolo: 7, volume: 9, anno: 1998,
pagine: 1431 - 1434
SICI:
0959-4965(1998)9:7<1431:RKAAIS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMINE TRANSAMINASE-K; BLOOD-PRESSURE REGULATION; CONJUGATE BETA-LYASE; PYRUVATE AMINOTRANSFERASE; BRAIN; KIDNEY; ACID; EXPRESSION; MICRODIALYSIS; PURIFICATION;
Keywords:
BRAIN; GLUTAMINE TRANSAMINASE K; KIDNEY; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; MEDULLA; SHR; WKY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
V. Kapoor et al., "REDUCED KYNURENINE AMINOTRANSFERASE-I ACTIVITY IN SHR RATS MAY BE DUETO LACK OF KAT-IB ACTIVITY", NeuroReport, 9(7), 1998, pp. 1431-1434

Abstract

KYNURENINE aminotransferase I(KAT-I), which also shows glutamine transaminase K (GTK) activity, catalyses the conversion of kynurenine to kynurenic acid, an endogenous glutamate antagonist. Both the GTK and KAT enzyme activities were found to be significantly reduced in kidney, brain and medulla oblongata homogenates of spontaneously hypertensive (SHR) compared to Wistar-Kyoto (WKY) rats. Enzyme activity stains on native gel separations of partially purified kidney homogenates was associated with two major bands of GTK (KAT-I)-activity in WKY and Wistarrats, KAT-Ia and KAT-Ib. SHR rats however showed only KAT-Ia activity. These findings suggest that the absence of KAT-Ib activity may result in a reduced ability to synthesise kynurenic acid in SHR rats, this may help to explain the enhanced sensitivity to glutamate seen in thisstrain. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:16:28