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Titolo:
EXPRESSION OF BCL-2 ONCOPROTEIN IN TRANSITIONAL-CELL CARCINOMA OF THEUPPER URINARY-TRACT
Autore:
NAKANISHI K; TOMINAGA S; KAWAI T; TORIKATA C; AURUES T; IKEDA T;
Indirizzi:
NATL DEF MED COLL,DIV ENVIRONM MED,RES INST TOKOROZAWA SAITAMA 359 JAPAN NATL DEF MED COLL,DEPT PATHOL TOKOROZAWA SAITAMA 359 JAPAN
Titolo Testata:
Virchows Archiv
fascicolo: 5, volume: 432, anno: 1998,
pagine: 445 - 450
SICI:
0945-6317(1998)432:5<445:EOBOIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL PELVIS; IMMUNOHISTOCHEMICAL EVALUATION; PROGNOSTIC-SIGNIFICANCE; PROTEIN EXPRESSION; UROTHELIAL TUMORS; PROSTATE-CANCER; P53; BREAST; IMMUNOREACTIVITY; ASSOCIATION;
Keywords:
TRANSITIONAL CELL CARCINOMA; UPPER URINARY TRACT; BCL-2 ONCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Nakanishi et al., "EXPRESSION OF BCL-2 ONCOPROTEIN IN TRANSITIONAL-CELL CARCINOMA OF THEUPPER URINARY-TRACT", Virchows Archiv, 432(5), 1998, pp. 445-450

Abstract

We investigated the immunoreactivity for bcl-2 oncoprotein in 154 cases of transitional cell carcinoma of the upper urinary tract (TCC-UUT)and its relation with the immunoreactivity for p53 oncoprotein and proliferating cell nuclear antigen (PCNA) immunoreactivity. Immunohistochemically, bcl-2 oncoprotein was recognized as positive in 29.2% of the samples. The immunoreactivity for bcl-2 oncoprotein was significantly (P < 0.05) correlated only with stage, though there was a borderlinecorrelation (P = 0.050) with PCNA immunoreactivity. Furthermore, in invasive TCC the immunoreactivity for bcl-2 oncoprotein was associated with PCNA immunoreactivity (P < 0.041). The 5-year disease-free and overall survival rates were 55.7% and 71.5%, respectively. A univariate analysis of survival revealed that stage, grade, pattern of growth, immunoreactivity for p53 oncoprotein, and PCNA immunoreactivity each hada significant effect on disease-free and overall survival rates, whereas the immunoreactivity for bcl-2 oncoprotein had no significant effect on either rate. In the final models of the multivariate analysis, stage was found to be the only prognostic factor for disease-free survival and for overall survival. Detection of immunoreactivity for bcl-2 oncoprotein appears to be of no real value in deciding the prognosis of TCC-UUT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:06:33