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Titolo:
SPONTANEOUS INFLAMMATORY BOWEL-DISEASE IN MULTIPLE MUTANT MOUSE LINES- ASSOCIATION WITH COLONIZATION BY HELICOBACTER-HEPATICUS
Autore:
FOLTZ CJ; FOX JG; CAHILL R; MURPHY JC; YAN LL; SHAMES B; SCHAUER DB;
Indirizzi:
MIT,DIV COMPARAT MED,45-106,77 MASSACHUSETTS AVE CAMBRIDGE MA 02139 MIT,DIV COMPARAT MED CAMBRIDGE MA 02139
Titolo Testata:
Helicobacter
fascicolo: 2, volume: 3, anno: 1998,
pagine: 69 - 78
SICI:
1083-4389(1998)3:2<69:SIBIMM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INTESTINAL INFLAMMATION; CHRONIC ACTIVE HEPATITIS; CD4(+) T-CELLS; ULCERATIVE-COLITIS; INTERLEUKIN-10-DEFICIENT MICE; HOMOSEXUAL MEN; SCID MICE; SP-NOV; ENTEROCOLITIS; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Foltz et al., "SPONTANEOUS INFLAMMATORY BOWEL-DISEASE IN MULTIPLE MUTANT MOUSE LINES- ASSOCIATION WITH COLONIZATION BY HELICOBACTER-HEPATICUS", Helicobacter, 3(2), 1998, pp. 69-78

Abstract

Background. Both genetic and microbial factors are thought to play a role in the development of inflammatory bowel disease (IBD): however, no causative microbial agent has been clearly defined for humans or animals. Normal flora or previously unrecognized intestinal pathogens may contribute to the development of disease in susceptible hosts. A newly recognized murine Helicobacter, H. hepaticus, causes hepatitis in mice and in one strain of mice is linked to liver cancer. This study investigates the association between colonization of the lower intestinal tract of multiple genetically altered lines of mice with H. hepaticus, and the occurrence of IBD. Materials and Methods. Rectal prolapse noted clinically in multiple genetically altered mouse lines was evaluated for the presence of H. hepaticus and histologic evidence of IBD. Fifty-five mice representing 11 different genetic alterations were evaluated. Results. H. hepaticus was detected in 85% of mutant mice with rectal prolapse. Histologic evidence of proliferative typhlitis, colitis or proctitis was present in 65% of the animals examined, 89% of which were positive for H. hepaticus as detected by species specific PCR. Conclusion. The presence of H. hepaticus in association with IBD in multiple lines of genetically altered mice suggests further studies are needed to test experimentally the role H. hepaticus plays in the development of IBD in susceptible mice. Additionally, specific mutant mouselines infected with H. hepaticus is in this study may provide additional models for elucidation of microbial and genetic factors in the pathogenesis of IBD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:52:37