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Titolo:
INCREASED STRIATAL DOPAMINE TRANSMISSION IN SCHIZOPHRENIA - CONFIRMATION IN A 2ND COHORT
Autore:
ABIDARGHAM A; GIL R; KRYSTAL J; BALDWIN RM; SEIBYL JP; BOWERS M; VANDYCK CH; CHARNEY DS; INNIS RB; LARUELLE M;
Indirizzi:
NEW YORK STATE PSYCHIAT INST & HOSP,UNIT 28,177 W 168TH ST NEW YORK NY 10032 YALE UNIV,DEPT PSYCHIAT NEW HAVEN CT 06520 YALE UNIV,DEPT DIAGNOST RADIOL NEW HAVEN CT 06510 VET ADM MED CTR W HAVEN CT 00000
Titolo Testata:
The American journal of psychiatry
fascicolo: 6, volume: 155, anno: 1998,
pagine: 761 - 767
SICI:
0002-953X(1998)155:6<761:ISDTIS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; AMPHETAMINE; BINDING; RELEASE; INVIVO; METABOLITES; DIALYSIS; D-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Abidargham et al., "INCREASED STRIATAL DOPAMINE TRANSMISSION IN SCHIZOPHRENIA - CONFIRMATION IN A 2ND COHORT", The American journal of psychiatry, 155(6), 1998, pp. 761-767

Abstract

Objective: The authors previously observed an increase in striatal dopamine transmission following amphetamine challenge in 15 untreated patients with schizophrenia compared to 15 matched healthy subjects. Thepurpose of this study was to replicate this finding in a new cohort of schizophrenic patients and healthy subjects. Method: Fifteen patients with schizophrenia and 15 healthy subjects matched for age, gender, ethnicity, and parental socioeconomic status were recruited for this study. Patients fulfilled DSM-IV criteria for schizophrenia, had no history of alcohol or substance abuse or dependence, and were neurolepticfree for a minimum of 21 days. Amphetamine-induced dopamine release was assessed by the reduction in dopamine Da receptor availability induced by an acute amphetamine challenge (0.3 mg/kg, intravenous bolus). Reduction in D-2 receptor availability was measured with single photonemission computed tomography and the D-2 receptor radiotracer [I-123]IBZM. Results: No differences were observed between patients with schizophrenia and the comparison group in D-2 receptor availability at baseline. Patients with schizophrenia exhibited a significantly larger reduction in D-2 receptor availability following acute amphetamine challenge than the comparison group. In this study, the effect size was smaller than in the first study. Excess dopamine release following amphetamine was associated with transient emergence or worsening of positivesymptoms. Conclusions: In this new cohort of subjects the authors replicated their initial observation of a dysregulation of striatal dopamine release in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 14:52:15