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Titolo:
REPRODUCIBILITY OF FUNCTIONAL TRANSCRANIAL DOPPLER SONOGRAPHY IN DETERMINING HEMISPHERIC LANGUAGE LATERALIZATION
Autore:
KNECHT S; DEPPE M; RINGELSTEIN EB; WIRTZ M; LOHMANN H; DRAGER B; HUBER T; HENNINGSEN H;
Indirizzi:
UNIV MUNSTER,DEPT NEUROL,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY
Titolo Testata:
Stroke
fascicolo: 6, volume: 29, anno: 1998,
pagine: 1155 - 1159
SICI:
0039-2499(1998)29:6<1155:ROFTDS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; BASAL CEREBRAL-ARTERIES; CORTICAL REORGANIZATION; PHANTOM-LIMB; ACTIVATION; HUMANS; TASKS; FMRI; PET;
Keywords:
FUNCTIONAL IMAGING; LANGUAGE; RELIABILITY; REPRODUCIBILITY; ULTRASONOGRAPHY, DOPPLER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S. Knecht et al., "REPRODUCIBILITY OF FUNCTIONAL TRANSCRANIAL DOPPLER SONOGRAPHY IN DETERMINING HEMISPHERIC LANGUAGE LATERALIZATION", Stroke, 29(6), 1998, pp. 1155-1159

Abstract

Background and Purpose-Since functional transcranial Doppler ultrasonography (fTCD) allows convenient and fully automated quantification oflanguage lateralization, it seems ideal for longitudinal studies of perfusion changes during deterioration as well as recovery of language functions. However, during serial examinations, the technical, stochastic, and physiological variabilities of cerebral blood flow velocities(CBFV) have to be considered. Therefore, before fTCD is accepted as atool for evaluation of changes in lateralization in the diseased state, its reliability in healthy subjects needs to be determined. Methods-We performed fTCD during a word generation task based on a previouslyvalidated technique with automated calculation of the averaged CBFV differences in the middle cerebral arteries providing an index of lateralization (LI), Results-(1) The accuracy of the LI as assessed by the confidence interval was better than 1% of the mean hemispheric difference. (2) On repeated examination, LIs obtained from 10 subjects showeda high test-retest reproducibility (Pearson product moment correlation coefficient r=0.95, P<0.0001), (3) On 10 repeated assessments of LI in the same subject, no practice effects were detected, Conclusions-Functional TCD is a suitable and very robust tool for the longitudinal quantitative measurement of cerebral language lateralization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:11:03